| 鸭疫里默氏菌对氟喹诺酮药物的主动外排作用 |
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| 引用本文： | 金龙翔,程龙飞,陈红梅,潘异哲,黄瑜.鸭疫里默氏菌对氟喹诺酮药物的主动外排作用[J].福建农业学报,2014(5):413-416. |
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| 作者姓名： | 金龙翔 程龙飞 陈红梅 潘异哲 黄瑜 |
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| 作者单位： | [1]福建省农业科学院畜牧兽医研究所,福建福州350013 [2]江西农业大学动物科学学院,江西南昌330045 |
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| 基金项目： | 现代农业产业技术体系建设专项（CARS-43）;福建省科技计划项目--省属公益类科研院所基本科研专项（2011R1025-6）;福建省农副业五新工程项目[闽发改（2012）931号] |
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| 摘 要： | 为研究鸭疫里默氏菌对诺氟沙星、恩诺沙星、环丙沙星、氧氟沙星、左氧氟沙星等氟喹诺酮类药物的主动外排机制，测定25株鸭疫里默氏菌临床分离株对氟喹诺酮类药物的最低抑菌浓度（M IC ），同时测定加入主动外排抑制剂碳酰氰间氯苯腙（CCCP）后的MIC ，对二者进行比较分析。结果表明，对5种氟喹诺酮类药物耐药的鸭疫里默氏菌比例分别为84％、72％、76％、68％和36％；76％的菌株同时耐受2种及以上药物。CCCP可以使耐药菌对除左氧氟沙星外药物的敏感性增加，提示主动外排在鸭疫里默氏菌对氟喹诺酮类药物的耐药机制中发挥重要的作用。
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| 关 键 词： | 鸭疫里默氏菌 氟喹诺酮类药物 主动外排 最低抑菌浓度 |
The Active Efflux of Riemerella Anatipestifer for Fluoroquinolone Antibiotics |
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| JIN Long-xiang,CHENG Long-fei,CHEN Hong-mei,PAN Yi-zhe,HUANG Yu.The Active Efflux of Riemerella Anatipestifer for Fluoroquinolone Antibiotics[J].Fujian Journal of Agricultural Sciences,2014(5):413-416. |
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| Authors: | JIN Long-xiang CHENG Long-fei CHEN Hong-mei PAN Yi-zhe HUANG Yu |
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| Institution: | 1. Institute of Animal Husbandry and Veterinary Medicine, Fujian Academy of Agricultural Sciences, Fuzhou, Fujian 350013, China; 2. Animal Science College of Jiangxi Agriculture University, Nanchang, Jiangxi 330045, China) |
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| Abstract: | To study the active efflux mechanism of Riemerella anatipestifer for fluoroquinolone antibiotics （FQNS ） such as norfloxacin ,enrofloxacin ,ciprofloxacin ,ofloxacin and levofloxacin ,the minimum inhibitory concentration （MIC） of 25 Riemerella anatipestifer isolates for FQNS was tested ,and simultaneously the MIC was detected after adding carbonylcyanide-m-chlorophenylhydrazone （CCCP） .The ratios of the FQNS-resistant strains were 84% , 72% ,76% ,68% and 36% ;76% of strains were resistant to two or more drugs .CCCP increased the sensitivity of the drug-resistant bacteria to FQNS （except levofloxacin ） , indicating that active efflux mechanism played an important role in resistance mechanisms to FQNS in Riemerella anatipestifer . |
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| Keywords: | Riemerella anatipestifer fluoroquinolone antibiotics the active efflux the minimum inhibitory concentration |
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