| 日粮硒对小鼠肾脏硒沉积及抗氧化酶基因表达的影响 |
| |
| 引用本文： | 刘碧涛,张琴,郑良焰,等.日粮硒对小鼠肾脏硒沉积及抗氧化酶基因表达的影响[J].中国畜牧兽医,2014,41(2):87-91. |
| |
| 作者姓名： | 刘碧涛 张琴 郑良焰 等 |
| |
| 摘 要： |
|
| 关 键 词： | 硒 肾脏硒沉积 抗氧化酶 基因表达 |
| 收稿时间： | 2013-07-12 |
Effect of Dietary Selenium on Selenium Deposition and Antioxidant Enzymes Gene Expression in Mouse Kidney |
| |
| LIU Bi-tao,ZHANG Qin,ZHENG Liang-yan,GUO Kai,YU Wen-lan,LIU Zheng-wei,GUO Cui-li,CHEN Ye,TANG Zhao-xin.Effect of Dietary Selenium on Selenium Deposition and Antioxidant Enzymes Gene Expression in Mouse Kidney[J].China Animal Husbandry & Veterinary Medicine,2014,41(2):87-91. |
| |
| Authors: | LIU Bi-tao ZHANG Qin ZHENG Liang-yan GUO Kai YU Wen-lan LIU Zheng-wei GUO Cui-li CHEN Ye TANG Zhao-xin |
| |
| Institution: | (College of Veterinary Medicine, South China Agricultural University, Guangzhou 510642, China) |
| |
| Abstract: | This study was to explore the effect of dietary selenium on selenium deposition and antioxidant enzymes gene expression in mouse kidney. Four groups （Ⅰ，Ⅱ，Ⅲ and Ⅳ）of mice were fed eight weeks with 0.045,0.1,0.4 and 0.8 mg/kg Se， respectively. The results showed that the levels of kidney selenium deposition increased with the increasing of dietary selenium, groupⅠ was significantly lower than other groups （P＜0.05）. Kidney selenium deposition among Ⅱ、Ⅲ、Ⅳ groups showed no significant differences when fed to the 56th day （P＞0.05）. The TrxR2 mRNA expression of groupⅠwas significantly lower than that of groups Ⅱ and Ⅲ （P<0.05）, and the two groups also showed significant differences（P＜0.05）. The SOD1 and SOD2 mRNA expression levels of groupⅠwere significantly lower than that of groups Ⅱ and Ⅲ （P＜0.05）. SOD2 expression showed significantly different between groups Ⅱ and Ⅲ（P＜0.05）, while SOD1 expression showed no significant differences between the two groups. The CAT mRNA expression levels of groupsⅠ and Ⅱ were significantly higher than that of group Ⅲ （P＜0.05）, there were no significant differences between groups Ⅰ and Ⅱ （P>0.05）. These results indicated that selenium could increase the level of kidney selenium deposition. With the feeding time increased, kidney selenium deposition in high-selenium group showed saturated. Se deficient and excessive could reduce the mRNA expression levels of kidney antioxidant genes (TrxR2, SOD1, SOD2 and CAT). |
| |
| Keywords: | selenium kidney selenium deposition antioxidant enzymes gene expression |
| 本文献已被 CNKI 等数据库收录！ |
| 点击此处可从《中国畜牧兽医》浏览原始摘要信息 |
| 点击此处可从《中国畜牧兽医》下载免费的PDF全文 |
|
