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| 青蒿散抗鸡球虫药效研究 | |
| 引用本文： | 牛彪,秦文文,郭文柱,张璞俊,马莉平,黄鑫,刘宇,梁剑平.青蒿散抗鸡球虫药效研究[J].中国畜牧兽医,2018,45(6):1683-1691. |
| 作者姓名： | 牛彪 秦文文 郭文柱 张璞俊 马莉平 黄鑫 刘宇 梁剑平 |
| 作者单位： | 1. 中国农业科学院兰州畜牧与兽药研究所, 农业部兽用药物创制重点实验室, 甘肃省新兽药工程重点实验室, 兰州 730050; 2. 和林格尔县农牧业局动物卫生监督所, 和林格尔 011500 |
| 基金项目： | 中国农业科学院科技创新工程（CAAS-ASTIP-2014-LZHPS-04） |
| 摘 要： | 为探讨青蒿散对鸡柔嫩艾美耳球虫（E.tenella）的防治效果，本试验选取90只健康黄羽肉鸡，分为6组，除空白对照组外，其余各组（感染对照组、药物对照组及青蒿散低、中、高剂量组）试验鸡均经口感染6×104个柔嫩艾美耳球虫孢子化卵囊，各试验组在接种前一天开始用药至试验结束。记录各组试验鸡的眼观病变、组织病理学检查、相对增重率、盲肠病变记分、血便记分、每克粪便中的卵囊数（OPG）、卵囊值及抗球虫指数（ACI）指标，评价青蒿散不同给药浓度的抗球虫效果。结果显示，空白对照组、感染对照组、药物对照组及青蒿散低、中、高剂量组的抗球虫指数分别为200.00、72.23、157.19、82.89、125.32和137.06，与感染对照组相比，药物对照组和青蒿散各剂量组的眼观病变、组织病理学检查均有所缓解，青蒿散能减轻病鸡盲肠的肿胀和出血等症状，且病鸡精神状态较感染对照组好；与感染对照组相比，各给药组的平均增重均有所升高，盲肠病变、卵囊值及血便情况减少。综上所述，青蒿散能缓解柔嫩艾美耳球虫侵染鸡盲肠所致的病理症状和组织病变，减少粪便中卵囊的排出数量，有一定的抗球虫效果，且给药浓度越高抗球虫效果越好，具有剂量依赖性。 |
| 关 键 词： | 青蒿散 柔嫩艾美耳球虫 抗鸡球虫 抗球虫指数 |
| 收稿时间： | 2017-12-04 |
Study on Anticoccidial Efficacy of Artemisia annua Powder |
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| NIU Biao,QIN Wenwen,GUO Wenzhu,ZHANG Pujun,MA Liping,HUANG Xin,LIU Yu,LIANG Jianping.Study on Anticoccidial Efficacy of Artemisia annua Powder[J].China Animal Husbandry & Veterinary Medicine,2018,45(6):1683-1691. | |
| Authors: | NIU Biao QIN Wenwen GUO Wenzhu ZHANG Pujun MA Liping HUANG Xin LIU Yu LIANG Jianping |
| Institution: | 1. Key Laboratory of New Animal Drug Project, Gansu Province, Key Laboratory of Veterinary Pharmaceutics Discovery, Ministry of Agricultural, Lanzhou Institute of Husbandry and Pharmaceutical Sciences of CAAS, Lanzhou 730050, China; 2. Animal Health Inspection Institute of Agriculture and Animal Husbandry Bureau of Helinger, Helinger 011500, China |
| Abstract: | In order to investigate the control effect of Artemisia annua powders on chicken coccidian,90 healthy yellow feather broilers were selected and divided into 6 groups.Except the blank control group,other chickens were infected with Eimeria tenella (E.tenella),with 6×104 sporulated oocysts,and each test group began to use drugs on the day before the vaccination,until to the end of the test.By recording the indexs of each test group,including their macroscopical lesion,histopathological examination,relative weight-growth rate,lesion scores of pathological changes of cecum,lesion scores of bloody stool,the number of oocysts (OPG),per gram of feces,oocyst score and anticoccidial index (ACI),the thesis made attempts to evaluate anticoccidia effects.The results revealed that the ACI of blank control group,infection control group,drug control group and low,middle and high dose groups of Artemisia annua powders were 200.00,72.23,157.19,82.89,125.32 and 137.06,respectively.Compared with infection control group,the macroscopical lesion,histopathological examination of drug control group and drug supplied groups of Artemisia annua powders were relieved.Artemisia annua powders could reduce sick chicken's cecum swelling and bleeding and other symptoms,and they were in much better spirits than infection control group.Compared with the infection control group,the average weight gain of each drug supply group were all increased,and their cecal lesion scores,oocyst score and bloody stools decreased.The results showed that Artemisia annua powders could alleviate pathological symptoms and tissue lesions infected by Eimeria tenella of chicken cecum,and reduce the amount of feces in the oocysts.The higher the concentration of administration,the better the anticoccidial effect,which was dose-dependent. |
| Keywords: | Artemisia annua powder Eimeria tenella anti-chicken coccidian anti-coccidia index |
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