Effect of SerpinE2 on metabolism of extracellular matrix |
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| Authors: | FENG Ying LIU Xiao E Xiao-qiang LI Xue-lian |
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| Institution: | 1. Department of Pharmacology, College of Pharmacy, Key Laboratory of Cardiovascular Medicine Research, Ministry of Education, Harbin 150001, China;
2. Department of Orthopaedics, The First Affiliated Hospital, Harbin Medical University, Harbin 150001, China |
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| Abstract: | Serpin peptidase inhibitor clade E member 2 (SerpinE2), a member of serine peptidase inhibitor super family, regulates multiple serine proteases. Extracellular matrix (ECM) plays an important role in stem cell differentiation, signal transduction, tumor metastasis, osteoarthritis physiological and pathological processes and so on. SerpinE2 regulates the protein of extracellular matrix by serine protease system and matrix metalloproteinase (MMP) system. In this paper, we elaborate the effect of SerpinE2 on metabolism of extracellular matrix, and it will provide new ideas to find new therapeutic targets. |
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| Keywords: | Serine peptidase inhibitor clade E member 2 Extracellular matrix Tumour Fibrosis |
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