Haemodynamic effects of hyoscine-N-butylbromide in ponies |
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| Authors: | TR GEIMER PM EKSTRÖM JW LUDDERS DF ERICHSEN† RD GLEED |
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| Institution: | *Department of Clinical Sciences, College of Veterinary Medicine, Cornell University, Ithaca, New York 14853–6401;?Boehringer Ingelheim Animal Health Inc., St Joseph, Missouri 64506–2202, USA |
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| Abstract: | The haemodynamic effects of hyoscine- N -butylbromide (0.30 mg/kg, intravenously) were studied in eight adult ponies in a blinded two-period crossover experiment with repeated measures. Values for heart rate were 63%, 48% and 13% greater than control values at 1, 16 and 46 min, respectively, after administration of hyoscine-N-butylbromide. Cardiac output increased by 16% at 16 min after drug injection. Mean right atrial pressure was decreased by 79%, 63%, 45% and 52% at 1, 16, 46 and 61 min, respectively, after drug administration. Stroke volume was decreased by 32% at 1 min and pulmonary arterial wedge pressure was decreased by 44% at 16 min. We detected no significant difference in mean systemic arterial pressure, mean pulmonary arterial pressure, systemic vascular resistance or pulmonary vascular resistance at any time. |
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