| 涂敷型直链淀粉手性固定相的制备及对外消旋体农药喹禾灵的分离研究 |
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| 引用本文： | 周志强,江树人,王敏,钱传范,杨舰.涂敷型直链淀粉手性固定相的制备及对外消旋体农药喹禾灵的分离研究[J].农药学学报,2000,2(1):91-93. |
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| 作者姓名： | 周志强 江树人 王敏 钱传范 杨舰 |
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| 作者单位： | 1.中国农业大学应用化学系,北京 100094 |
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| 摘 要： | 不对称分离研究已引起人们广泛的关注 ,高效液相色谱法是其中最重要的研究手段之一 ,它主要包括手性固定相法、流动相添加剂法和衍生化法 ,其中手性固定相法的应用最为广泛。纤维素和淀粉是最易得的具有光学活性的天然聚合物 ,很早就用于手性拆分 1 ] 。直链淀粉三苯基酯类手性固定相的手性拆分能力较弱 ,但其三苯基氨基甲酸酯类却有很强的手性拆分能力 2 ]。近年来 ,我们在这一领域进行了探讨 ,并取得了较好结果 3～ 7]。光学异构体药物往往表现出不同的药代和药理学行为 8] ,而手性农药也具有相似的特性 ,同一种农药的几种光学异构体…
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| 关 键 词： | 高效液相色谱 直链淀粉-三(3 5-二甲基苯基氨基甲酸酯) 喹禾灵 手性拆分 |
Chiral Separation of Quizalofop on Amylose-Chiral Stationary Phase by HPLC |
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| Zhou Zhi-qiang,Jiang Shu-ren,Wang Min,Qian Chuan-fan and Yang Jian.Chiral Separation of Quizalofop on Amylose-Chiral Stationary Phase by HPLC[J].Chinese Journal of Pesticide Science,2000,2(1):91-93. |
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| Authors: | Zhou Zhi-qiang Jiang Shu-ren Wang Min Qian Chuan-fan and Yang Jian |
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| Institution: | 1.Department of Applied Chemistry2.China Agricultural University, |
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| Abstract: | Amylose se-tris(3,5-2 meth phenyl carbamate) was synthesized and used as the chiral stationary phase upon adsorption over silica gel. This stationary phase offered a practically useful chiral column with a high enantiomer separability. Amylose was allowed to react with an excess of 3,5-2 meth phenyl carbamate in pyridine for 48h. The obtained carbamate was dissolved and adsorbed on silica gel which has been treated with 3-aminopropyltriethoxysilane. The weight ratio of the carbamate to the silica gel was 0.45/2.55. The quizalofop was resoluted on amylose tris(3,5 dimethphenylcarbamate) chiral stationary phase. Separation was carried out with a hexane/2 propanol mixture at a flow rate of 0.5 mL·min-1 at room temperature. The effects of 2-propanol concentration on the retention and resolution had been investigated |
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| Keywords: | HPLC Amylose tris(3 5 dimethphenylcarbamate) Enantiomeric separation Quizalofop |
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