| 黄葵素对结核分枝杆菌的抑杀作用研究 |
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| 作者姓名： | 伍参荣 蔡锐 李珊 申可佳 贾本真 李芳荣 |
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| 作者单位： | 1.湖南中医药大学病原免疫学教研室,湖南长沙410208;2.湖南中医药研究院,湖南长沙410006 |
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| 摘 要： | Objective To evaluate the antituberculous activities of Huangkuisu (HISS). Meth-ods lOStandard human strains of mycobacterium tuberculosis (H37RV) and multi-drug resistant TBstrainswere inoculated in different concentrations of HISS, blank control and positive TB drug culture medium()observe the growth of mycobacterium tuberculosis and evaluate the antibacterial activity in vitro.②Certain number of standard strains of Mycobacterium tuberculosis H37Rv and drug-resistant strains were injected into the tail vein()establish a mouse model of mycobacterium tuberculosis infection. The mice were randomly divided into treatment group, rifampicin, HISS treatment group treated lasting for 6 weeks; the control group was given normal saline. The antibacterial activity in vivo were evaluated()compare the treatment results according()the pathological changes in lung and spleen tissues (HE staining and acid-fast staining) and charging amount of bacteria. Results lOthe bactreial colonies were grew normally in model group, but were not grew in
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| 关 键 词： | 黄葵素 结核分枝杆菌川"鼠 抗菌活性 |
Effects of Huangkuisu on killing and suppressing mycobacterium tuberculosis |
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| Authors: | WU Can-rong CAI Rui LI Shan SHEN Ke-_ji JIA Ben-zheng LI Fang-rong |
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| Institution: | 1. TCM University of Hunan, Changsha, Hunan 410208, China;2. Hunan Academy of Chinese Medicine, Changsha, Hunan 410006,China) |
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| Abstract: | |
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| Keywords: | Huangkuisu (HISS) mycobacterium tuberculosis mice pharmacodynamics |
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