A New Dibenz[b,e]oxepine Derivative, 1-Hydroxy-10-methoxy-dibenz[b,e]oxepin-6,11-dione,from a Marine-Derived Fungus,Beauveria bassiana TPU942 |
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| Authors: | Hiroyuki Yamazaki Henki Rotinsulu Tsuyoshi Kaneko Kazuki Murakami Hiromu Fujiwara Kazuyo Ukai Michio Namikoshi |
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| Institution: | 1. Department of Natural Product Chemistry, Tohoku Pharmaceutical University, Sendai 981-8558, Japan; Email: (H.Y.); (H.R.); (T.K.); (K.M.); (H.F.); (K.U.);2. Faculty of Agriculture, Indonesia Development University, Manado 95361, Indonesia |
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| Abstract: | 1-Hydroxy-10-methoxy-dibenzb, e]oxepin-6,11-dione (1) was obtained from the culture broth of a marine-derived fungus, Beauveria bassiana TPU942, isolated from a marine sponge collected at Iriomote Island in Okinawa, together with two known compounds, chrysazin (2) and globosuxanthone A (3). The structure of 1 was elucidated on the basis of its spectroscopic data (HREIMS, 1D and 2D NMR experiments including 1H–1H COSY, HMQC and HMBC spectra). Dibenzb, e]oxepines are rare in nature, and only six natural products have been reported. Therefore, compound 1 is the seventh natural product in this class. Compounds 2 and 3 showed an antifungal activity against Candida albicans, and 3 inhibited the cell growth against two human cancer cell lines, HCT-15 (colon) and Jurkat (T-cell lymphoma). Compound 1 did not show an apparent activity in the same bioassays. |
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| Keywords: | dibenzooxepine derivative 1-hydroxy-10-methoxy-dibenz[b e]oxepin-6 11-dione marine-derived fungus fungal metabolites |
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