| 九里香雌激素样作用及其对关节保护作用的初步研究 |
| |
| 引用本文： | 曾发挥,刘海清,李林福等.九里香雌激素样作用及其对关节保护作用的初步研究[J].安徽农业科学,2013(24):9948-9950. |
| |
| 作者姓名： | 曾发挥 刘海清 李林福等 |
| |
| 作者单位： | 赣南医学院药学院,江西赣州341000 |
| |
| 基金项目： | 江西省教育厅科技项目（GJJ13669）;赣南医学院人才引进启动基金（No.201102）;赣南医学院校级课题（YB201012）. |
| |
| 摘 要： | 目的]研究九里香的雌激素样作用及其对关节的影响.方法]取60只大鼠,随机分成6组,每组10只,分别为假手术组、去卵巢对照组、尼尔雌醇对照组和九里香低、中、高剂量组.以大鼠卵巢去除术为模型,术后假手术组和去卵巢对照组均给予浓度0.8％的CMC-Na,尼尔雌醇对照组给药剂量为0.5 mg/kg,均连续给药8周,末次给药后检测子宫质量和血清中雌二醇水平,并检测血清及关节液中透明质酸的含量.结果]九里香各剂量组子宫湿重、血清中雌二醇水平和关节液中透明质酸的含量均比尼尔雌醇对照组低,但比去卵巢对照组高,且与九里香剂量呈正相关,均呈显著性差异;而血清中透明质酸的含量与九里香剂量呈负相关,差异显著（P＜0.05）.结论]九里香具有雌激素样生物活性,可通过影响透明质酸水平保护关节软骨.
|
| 关 键 词： | 九里香 雌激素 子宫质量 透明质酸 关节液 |
Preliminary Research on Estrogen-like Effect of Murraya exotica （L.） and the Chondro Protection Activity |
| |
| Institution: | ZENG Fa-hui et al (College of Pharmacy, Gannan Medical University, Ganzhou, Jiangxi 341000) |
| |
| Abstract: | Objective ] To research on estrogen-like effect of Murraya exotica （ L. ） and the chondro protection activity. Method] Sixty rats were randomly divided into six groups, ten rats were a group. They were sham operation group, ovariectomized group, nilestriol group, low, middle, and high-dosage M. exotica group. Ovariectomized rats were duplicated as a model, 0.8% CMC-Na was administrated in sham opera- tion group and ovariectomized group after operation. 0.5 mg/kg nilestriol was designed as positive control. After eight weeks, the weight of u- terus, the contents of estradiol in the serum were determined, the contents of hyaluronic acid in the serum and synovia were also determined. Result] The weights of uterus, the content of estradiol in the serum, and the hyaluronic acid inthe synovia in different dosages of M. exotica group were much lower than those in nilestriol group, but higher than those in ovariectomized group. They were positively related to the dosa- ges of M. exotica and showed significant difference. Conversely, the hyaluronic acid in the serum exhibited negatively related to those dosages significantly. Conclusion] M. exotica exhibit estrogen-like activity, which protect the chondrocyte in the joints through influence on the ex- pression of hyaluronic acid. |
| |
| Keywords: | M exotica Estrogen Uterus weight Hyaluronic acid Synovia |
| 本文献已被 CNKI 维普 等数据库收录！ |
|
