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| 茎直黄芪中毒中药复方预防解毒散急性和亚慢性毒性试验 | |
| 引用本文： | 陶蕾,郝宝成,王学红,陆锡宏,赵凤舞,王保海,刘建枝,次仁多吉,梁剑平.茎直黄芪中毒中药复方预防解毒散急性和亚慢性毒性试验[J].中兽医医药杂志,2013,32(2):20-22. |
| 作者姓名： | 陶蕾 郝宝成 王学红 陆锡宏 赵凤舞 王保海 刘建枝 次仁多吉 梁剑平 |
| 作者单位： | 1. 兰州职业技术学院,甘肃兰州730070;中国农业科学院兰州畜牧与兽药研究所 农业部创新兽药重点实验室,甘肃兰州730050 2. 中国农业科学院兰州畜牧与兽药研究所 农业部创新兽药重点实验室,甘肃兰州,730050 3. 西藏农科院畜牧兽医研究所,西藏拉萨,850000 |
| 基金项目： | 西藏横向委托项目“预防动物疯草中毒解毒新制剂的研制”(2011-2012) |
| 摘 要： | 为评价茎直黄芪中药复方解毒散的安全性,进行了茎直黄芪中药复方解毒散对小鼠的急性毒性和亚慢性毒性试验研究。采用改良Karber法测得茎直黄芪中药复方解毒散对小鼠的口服急性毒性LD50为（176.91±22.70）g/kg,95%可信限为156.60-202.00 g/kg,属低毒;采用经口灌胃法对小鼠连续给药7 d,7 d后对小鼠各项生理指标的测定结果表明,茎直黄芪中药复方解毒散在使用剂量范围内对小鼠的行为、体质量、饮食状况、生理和生化指标均无不良影响。在亚慢性毒性试验中,给药7 d后各给药组小鼠肾脏脏器系数与对照组差异不显著（P〉0.05）;各种酶指标与对照组亦无显著性差异（P〉0.05）。由此可知,茎直黄芪中药复方预防解毒散毒性极低,使用安全。 |
| 关 键 词： | 茎直黄芪中药复方预防解毒散 急性毒性 亚慢性毒性 LD50 |
Studies on the acute and sub-chronic toxicity of Chinese herbal compound antidote against locoweedpoisoning |
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| TAO Lei,HAO Bao-cheng,WANG Xue-hong,LU Xi-hong,ZHAO Feng-wu,WANG Bao-hai,LIU Jian-zhi,Ciren Duoji,LIANG Jian-ping.Studies on the acute and sub-chronic toxicity of Chinese herbal compound antidote against locoweedpoisoning[J].Journal of Traditional Chinese Veterinary Medicine,2013,32(2):20-22. | |
| Authors: | TAO Lei HAO Bao-cheng WANG Xue-hong LU Xi-hong ZHAO Feng-wu WANG Bao-hai LIU Jian-zhi Ciren Duoji LIANG Jian-ping |
| Institution: | 1.Lanzhou Vocational Technical College,Lanzhou Gansu 730070;2.Key Laboratory of New Animal Drug Project,Gansu Province/Key Laboratory of Veterinary Pharmaceutics Discovery,Ministry of Agricultural/Lanzhou Institute of Husbandry and Pharmaceutical Sciences,CAAS,Lanzhou Gansu 730050;3.Research lnstitute of Animal Husbandry and Veterinary Medicine,Tibet Academy of Agricultural Sciences, Lhasa Tibet 850000,China) |
| Abstract: | Acute and sub-chronic toxicity of Chinese herbal compound antidote against locowee-dpoisoning was determined to evaluate its drug safety.In the acute toxicity test,different concentration of the compound was given to mice in 9 groups by intragastric administration for continuous 7 days,and the other 10 mice were given with normal saline as control.In the sub-chronic toxicity test,mice in 3 groups were administrated with high,middle and low dose of the compound by gavage for continuous 14 days.The results showed that the median lethal dose（LD50） of the herbal compound was（176.91±22.70） g/kg by Karber method,and it had no effect on the performance,behavior,blood index,biochemistry index and organ coefficients of mice after administration for 7 days.Sub-chronic toxicity test showed there was no significant difference in mice body weight,blood routine index,biochemistry index and morphological observation between experimental and control group on 1st and 14th after administration.It is concluded that Chinese herbal compound antidote is not toxic and has no potential adverse effect on mice for long-time use. |
| Keywords: | Chinese herbal compound antidote locoweedpoisoning acute and sub-chronic toxicity LD50 |
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