Efficacy of an oral live vaccine for veterinary use against pseudotuberculosis |
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| Authors: | Benoît Quintard Thierry Petit Nathalie Ruvoen Elisabeth Carniel Christian E Demeure |
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| Institution: | a Muséum de Besançon, La Citadelle, 25000 Besançon, France;b Zoo de La Palmyre, 17570 Les Mathes, France;c Ecole Nationale Vétérinaire, route Gachet, 44300 Nantes, France;d Yersinia Research Unit, Institut Pasteur, 28 rue du Dr Roux, 75724 Paris, France |
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| Abstract: | Pseudotuberculosis, an infection caused by the ubiquitous enteropathogenic bacterium Yersinia pseudotuberculosis, is a recurrent veterinary problem in livestock and zoo animals. The only vaccine currently available in zoos is Pseudovac (a mixture of killed strains of various serotypes), but its efficacy is not well established. We show here that Pseudovac does not protect guinea pigs against a severe Y. pseudotuberculosis infection. We thus evaluated the possibility of using a live attenuated Y. pseudotuberculosis strain (IP32680) as an oral vaccine against animal pseudotuberculosis. We report that IP32680 is avirulent for guinea pigs and induces a strong IgG response against various serotypes of Y. pseudotuberculosis. One and two oral inoculations of IP32680 provided 50% and 83% protection, respectively against a severe infection with a highly pathogenic strain. The avirulent Y. pseudotuberculosis IP32680 is therefore much more protective than Pseudovac and may represent a valuable oral vaccine against pseudotuberculosis in zoo animals. |
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| Keywords: | Yersinia pseudotuberculosis Pseudotuberculosis Pseudovac Oral Vaccine Serotype Guinea pig IgG |
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