| 昆虫神经肽抑咽侧体素及其类似物的研究进展 |
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| 引用本文： | 汪梅子,金小宇,周源琳,杨新玲.昆虫神经肽抑咽侧体素及其类似物的研究进展[J].农药学学报,2019,21(3):255-272. |
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| 作者姓名： | 汪梅子 金小宇 周源琳 杨新玲 |
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| 作者单位： | 中国农业大学 理学院 应用化学系，北京 100193 |
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| 基金项目： | 国家自然科学基金（21877126，21372257，20972185&20672138）；国家重点研发计划（2017YFD0200504） |
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| 摘 要： | 抑咽侧体素 (ASTs) 是一类由昆虫脑神经细胞分泌，通过作用于咽侧体进而抑制保幼激素 (JH) 合成与释放的昆虫神经肽。因其具有调控昆虫生长、发育和生殖等生理过程的功能，被认为是一类潜在的害虫控制剂。本文在简介了昆虫神经肽在害虫防治中的应用基础上，综述了昆虫神经肽抑咽侧体素的发现、类别和功能，并结合本研究组的工作，重点介绍抑咽侧体素及其类似物的结构修饰和优化、活性构象及构效关系研究，同时也介绍了抑咽侧体素及其类似物的受体和作用机制研究进展。最后，展望了该领域的未来发展趋势，期望为新的生态友好型农药的研发提供一定的参考作用。
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| 关 键 词： | 昆虫神经肽 抑咽侧体素 抑咽侧体素类似物 结构修饰 构效关系 保幼激素 作用机制 |
| 收稿时间： | 2019/5/16 0:00:00 |
Research progress of insect neuropeptide allatostatins and their analogues |
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| WANG Meizi,JIN Xiaoyu,ZHOU Yuanlin and YANG Xinling.Research progress of insect neuropeptide allatostatins and their analogues[J].Chinese Journal of Pesticide Science,2019,21(3):255-272. |
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| Authors: | WANG Meizi JIN Xiaoyu ZHOU Yuanlin and YANG Xinling |
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| Institution: | Department of Applied Chemistry, College of Science, China Agricultural University, Beijing 100193, China |
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| Abstract: | Allatostatins (ASTs) are a kind of insect neuropeptides secreted from insect brain nerve cells. ASTs can inhibit the biosynthesis and release of juvenile hormone (JH) by influencing corpora allata (CA). Given their influence on the insect growth, development, reproduction and other physiological processes, ASTs are considered as potential pest control agents. Based on a brief introduction of insect neuropeptides'' potential application in the field of pest control, the discovery, classification and function of allatostatins have been reviewed in this paper. According to the recent studies on ASTs and their analogues in our research group, the research progress in the area of structure modification and optimization of allatostatins, active conformation and the structure-activity relationship of ASTs analogues and their receptor and mode of action were summarized. The outlook of ASTs and their analogues as the candidates of eco-friendly pesticide is also proposed in this review, which were expected to provide a reference for the development of novel eco-friendly pesticides. |
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| Keywords: | insect neuropeptides allatostatins allatostatins analogues structure modification structure-activity relationship juvenile hormone mode of action |
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