Azotemia and mortality among Babesia microti-like infected dogs |
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| Authors: | Camacho A Tomas Guitian E Javier Pallas Estrella Gestal Juan Jesus Olmeda A Sonia Goethert Heidi K Telford Sam R Spielman Andrew |
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| Institution: | Laboratorio Lema & Bandín, Calle Lepanto 5, bajo, 36201 Vigo, Spain. atcamacho@teleline.es |
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| Abstract: | Babesia microti-like piroplasms are a recently recognized cause of illness in dogs in northwest Spain. Our objective was to describe the clinical characteristics and investigate the risk factors for azotemia and death among 58 B microti-like infected dogs. Twenty-one of the 58 (36%) dogs were azotemic at the time that the infection was diagnosed. The case fatality rate during the following week was 22%. Dogs with azotemia at the time of diagnosis were 10 times (95% CI, 3.26-28.8) more likely to die during the following week. Azotemia was the main cause of death for B microti-like infected dogs (attributable fraction = 90%). Severe anemia was present in 45 of the 58 (78%) dogs. Azotemic dogs also presented with hyperphosphatemia, hypoalbuminemia, hypercholesterolemia, proteinuria, and high urine protein: creatinine ratios, suggesting a glomerular component to the disease. Age was the only factor significantly associated with the risk of azotemia (P = .042): on average, a 4-year age increase doubled the risk of an infected dog being azotemic. The only factor significantly associated with mortality was azotemia (P = .001). We concluded that B microti-like infection is associated with a high risk of azotemia and mortality. |
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| Keywords: | Epidemiology Nephropathy Piroplasmosis Polymerase chain reaction Theileria annae |
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