| 豫北地区临床分离鸡大肠杆菌的体外抑菌作用测定 |
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| 引用本文： | 王海蓝.豫北地区临床分离鸡大肠杆菌的体外抑菌作用测定[J].中国兽药杂志,2009,43(7):20-23. |
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| 作者姓名： | 王海蓝 |
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| 作者单位： | 河南省康星药业有限公司 |
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| 基金项目： | 致谢向本公司贾艳华同志在使用SPSS软件进行数据分析方面的帮助表示感谢. |
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| 摘 要： | 为了有效地治疗鸡大肠杆菌病,采用微量倍比稀释方法测定了17种抗菌药物对临床分离的豫北地区15株鸡大肠杆菌的体外最小抑菌浓度（MIC）,并根据其MIC及MIC范围（MICRange）使用SPSS 13.0中Probit过程计算出17种抗菌药物的MIC50和MIC90。结果表明：多粘菌素B的抑菌作用最强,MIC50、MIC90分别为0.11、0.87μg/mL;加替沙星的抑菌作用次之,MIC50、MIC90分别为2.53、3.88μg/mL,其它3种药物恩诺沙星、左氧氟沙星、环丙沙星的抑菌作用相当,但不及加替沙星,MIC50、MIC90分别为10.11-11.79μg/mL、15.16-21.13μg/mL;多西环素和阿莫西林等12种抗菌药物的抑菌作用较小,MIC50、MIC90分别为18.53-388.50μg/mL和30.59-713.42μg/mL。
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| 关 键 词： | 鸡大肠杆菌 最低抑菌浓度 微量稀释法 |
| 收稿时间： | 2/9/2009 12:00:00 AM |
| 修稿时间： | 2009/5/19 0:00:00 |
In vitro antibacterial activity against chicken Colibacillus isolated in north of Henan Province |
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| wanghailan.In vitro antibacterial activity against chicken Colibacillus isolated in north of Henan Province[J].Chinese Journal of Veterinary Drug,2009,43(7):20-23. |
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| Authors: | wanghailan |
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| Institution: | Henan Province Health Star Pharmaceutical (Group) CO., LTD |
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| Abstract: | The sensitivity effects for 17 antibacterial medicines on 15 strains chicken E. coli were studied according to broth microdilution method. The results showed that polymycin B had strong antibacterial activities against chicken E. coli in vitro. The MIC50 was 0.11 μg/mL, the MIC9o was 0.87 μg/mL. Gatifloxacin was poor active against chicken E. coli The MIC50 and MICgo was 2.53 μg/mL, 3.88 μg/mL. The antibacterial activities of those 3 quinolones in vitro were similar but somewhat weaker than gatifloxacin. The 3 quinolones MIC50 and MIC90 were 10.11 - 11.79 μg/mL, 15.16 - 21.13 μg/mL,respectively. The other 12 antibacterial drugs showed weak power on E. coli, whose MIC50 and MICgo were 18.53 - 388.50 μg/mL, 30.59 - 713.42 μg/mL. |
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| Keywords: | poultry chicken MIC in vitro microdilution methd |
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