A highly conserved neutralizing epitope on group 2 influenza A viruses |
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| Authors: | Ekiert Damian C Friesen Robert H E Bhabha Gira Kwaks Ted Jongeneelen Mandy Yu Wenli Ophorst Carla Cox Freek Korse Hans J W M Brandenburg Boerries Vogels Ronald Brakenhoff Just P J Kompier Ronald Koldijk Martin H Cornelissen Lisette A H M Poon Leo L M Peiris Malik Koudstaal Wouter Wilson Ian A Goudsmit Jaap |
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| Institution: | Department of Molecular Biology, Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA. |
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| Abstract: | Current flu vaccines provide only limited coverage against seasonal strains of influenza viruses. The identification of V(H)1-69 antibodies that broadly neutralize almost all influenza A group 1 viruses constituted a breakthrough in the influenza field. Here, we report the isolation and characterization of a human monoclonal antibody CR8020 with broad neutralizing activity against most group 2 viruses, including H3N2 and H7N7, which cause severe human infection. The crystal structure of Fab CR8020 with the 1968 pandemic H3 hemagglutinin (HA) reveals a highly conserved epitope in the HA stalk distinct from the epitope recognized by the V(H)1-69 group 1 antibodies. Thus, a cocktail of two antibodies may be sufficient to neutralize most influenza A subtypes and, hence, enable development of a universal flu vaccine and broad-spectrum antibody therapies. |
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