| 液相色谱串联质谱测定水产品中吩噻嗪类药物残留的研究 |
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| 引用本文： | 李春风,岳振峰,赵凤娟,华红慧,韩瑞阳,李丽苏.液相色谱串联质谱测定水产品中吩噻嗪类药物残留的研究[J].中国兽医学报,2010,30(3). |
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| 作者姓名： | 李春风 岳振峰 赵凤娟 华红慧 韩瑞阳 李丽苏 |
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| 作者单位： | 1. 华中农业大学,动物医学院,湖北,武汉,430070
2. 深圳出入境检验检疫局,食品检验检疫技术中心,广东,深圳,518067 |
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| 摘 要： | 建立了水产品中氯丙嗪、乙酰丙嗪、丙酰丙嗪、异丙嗪、甲苯噻嗪等5种吩噻嗪类药物多残留的液质联用确证方法。用碱性乙睛萃取样品中的5种吩噻嗪类药物,然后用HLB固相萃取柱净化,以YMC-PackProC18色谱柱为分离柱,在正离子模式下以电喷雾电离串联质谱仪进行测定。在1.0、2.0、4.0ng/g3个质量浓度水平进行验证试验,方法的线性范围为0.5～5.0ng/g,总体平均回收率为75.7%～87.7%,相对标准偏差为9.0%～15.2%。该方法简便、快速、准确,各项技术指标满足国内外法规的要求,可用于水产品中吩噻嗪类药物残留的确证检测。
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| 关 键 词： | 吩噻嗪类 多残留 液相色谱-质谱联用仪 测定 水产品 |
The study on detecting residues of phenothiazines in aquatic products using high-performance liquid chromatography tandem electrospray mass spectrometry (LC/MS/MS) |
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| LI Chun-feng,YUE Zhen-feng,ZHAO Feng-juan,HUA Hong-hui,HAN Rui-yang,LI Li-su.The study on detecting residues of phenothiazines in aquatic products using high-performance liquid chromatography tandem electrospray mass spectrometry (LC/MS/MS)[J].Chinese Journal of Veterinary Science,2010,30(3). |
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| Authors: | LI Chun-feng YUE Zhen-feng ZHAO Feng-juan HUA Hong-hui HAN Rui-yang LI Li-su |
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| Institution: | LI Chun-feng1,YUE Zhen-feng2,ZHAO Feng-juan2,HUA Hong-hui2,HAN Rui-yang2,LI Li-su2 (1.College of Veterinary Medicine,Huazhong Agricultural University,Wuhan 430070,China,2.Food Inspection Center of Shenzhen Entry-Exit Inspection , Quarantine Bureau,Shenzhen,Guangdong 518067,China) |
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| Abstract: | A confirmative method is developed with high-performance liquid chromatography tandem electrospray mass spectrometry (LC/MS/MS) to detect 5 residues of phenothiazines in aquatic products,which include chlorpromazine,acepromazine,propriopromazine,promethazine and xylazine.In the method,the 5 residues are extracted with alkalized acetonitrile,cleaned with HLB solid phase extraction column.Then the reconstituted sample solution is analyzed by LC/MS/MS in positive mode,with YMC-Pack Pro C18 column as the separa... |
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| Keywords: | Phenothiazines multi-residues LC/MS/MS determination aquatic products |
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