| 红菇提取液对大龄小鼠抗氧化作用的研究 |
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| 引用本文： | 曾诗媛,甘耀坤,叶楚芳.红菇提取液对大龄小鼠抗氧化作用的研究[J].安徽农业科学,2009,37(16):7464-7466. |
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| 作者姓名： | 曾诗媛 甘耀坤 叶楚芳 |
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| 作者单位： | 玉林师范学院化学与生物系,广西玉林,537000;玉林师范学院化学与生物系,广西玉林,537000;玉林师范学院化学与生物系,广西玉林,537000 |
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| 基金项目： | 广西科技厅自然科学基金，广西教育厅科研项目 |
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| 摘 要： | 目的]探讨红菇子实体提取液对大龄小鼠的抗氧化性能及其作用机理。方法]将大龄小鼠20只随机分为4组：1组为大龄小鼠对照组,仅饲喂基础饲料和水 2、3、4组分别为大龄小鼠红菇低、中、高剂量组,这3组在饲喂基础饲料和水的基础上,每日早上9：00分别进行人工灌喂浓度为100、150、200 mg/ml的红菇提取液,灌喂量为0.2 ml/10 g小鼠体重,另外再设一小龄小鼠比较组（5只,仅饲喂基础饲料和水）,连续喂养21 d后,检测各组小鼠脑、心、肝组织内超氧化物歧化酶（SOD）活性和丙二醛（MDA）含量。结果]大龄小鼠红菇低、中、高剂量组分别与大龄小鼠对照组比较,其大脑、心肌、肝脏组织内SOD活性均有升高,MDA含量均有降低,并且随着浓度的升高差异性增大 大龄小鼠对照组与小龄小鼠比较组比较,SOD活性和MDA含量存在极显著差异（P〈0.01） 但大龄小鼠红菇高剂量组与小龄小鼠比较组比较,SOD活性和MDA含量则没有显著差异（P（0.05）。结论]红菇提取液可升高大龄小鼠组织的SOD活性,降低MDA含量,其升高或降低的幅度基本到达小龄小鼠的水平,红菇含有某些抗氧化成分,对大龄小鼠具有抗氧化和延缓衰老之功效。
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| 关 键 词： | 红菇 大龄小鼠 SOD MDA 抗氧化 |
Study on Effect of Russula Extracting Solution on Anti-oxidation of the Elder Mice |
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| Institution: | ZENG Shi-yuan et al ( Chemistry and Biology Department of Yulin Normal University, Yuhn, Guangxi 537000) |
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| Abstract: | Objective] The aim was to study the effect of extracting solution from russula fruiting body on anti-oxidation of the elder mice and its mechanism.Method] The 20 elder mice were divided into four groups,group I was control group of the elder mice,only fed with the foundational feed and water;group II,group III and group IV were low dose russula group,middle dose russula group and high dose russula group.The three groups not only fed with the foundational feed and water,but also fed with 100,150 and 200 mg/ml extracting solution from russula fruiting body,the feeding amount by 0.2 ml/10 g mice weight at the 9 am.Group V was compared group of mice(5 mice,only fed with the foundational feed and water).After treated continuously 21 days,the MDA content and SOD activity in the brain,heart and liver of mice was determined.Results] Compared with the low,middle,high dose russula group and control group of the elder mice,the SOD activity in the brain,heart and liver of the low,middle,high dose russula group was notably higher,the MDA content was notably lower,where the high dose russula group was the most significant.Compared with the control group of the elder mice and compared group of young mice,the MDA content and the SOD activity was significantly difference(P<0.01).But compared with the high dose russula group and compared group of young mice,the MDA content and SOD activity was not significantly difference(P<0.05).Conclusion] Extracting solution from russula fruiting body could improve superoxide dismutase(SOD) activity of the elder mice tissue,and decrease the MDA content.The range of improving or descending reached to the lever of young mice.Russula has some antioxidant components,and has some effect on antioxidation and anti-aging. |
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| Keywords: | Russula The elder mice SOD MDA Anti-oxidation |
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