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Intravenous vitamin K1 normalises prothrombin time in 1 hour in dogs with anticoagulant rodenticide toxicosis |
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| Authors: | ET Mooney G Agostini C Griebsch M Hickey |
| Institution: | 1. Sydney School of Veterinary Science, University of Sydney, New South Wales, Australia;2. Sydney School of Veterinary Science, University of Sydney, New South Wales, Australia
U-Vet Animal Hospital Werribee, Faculty of Veterinary and Agricultural Sciences, University of Melbourne, Victoria, Australia |
| Abstract: | Four dogs with anticoagulant rodenticide toxicosis were treated with intravenous vitamin K1 in lieu of plasma transfusion due to client cost constraints. Two dogs experienced a suspected anaphylactoid reaction, necessitating cessation of the treatment in one dog. Prothrombin time was rechecked 1 h after treatment in the remaining three dogs and all results were within the normal reference range. All four dogs were discharged from hospital within 48 h of presentation. Intravenous vitamin K1 rapidly reverses the coagulopathic state in dogs with anticoagulant rodenticide toxicosis. It is a viable alternative therapy to plasma transfusion if circumstances preclude its use; however, patients must be monitored for anaphylactoid reactions. |
| Keywords: | anaphylactoid dogs phytomenadione rodenticide vitamin K1 |