Recombinant S3Pvac-phage anticysticercosis vaccine: Simultaneous protection against cysticercosis and hydatid disease in rural pigs |
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| Authors: | Morales Julio de Aluja Aline S Martínez Jose Juan Hernández Marisela Rosas Gabriela Villalobos Nelly Hernández Beatriz Blancas Abel Manoutcharian Karen Gevorkian Goar Cervantes Jacquelynne Díaz Alicia Fleury Agnes Fragoso Gladis Larralde Carlos Sciutto Edda |
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| Institution: | Instituto de Investigaciones Biomédicas, Universidad Nacional Autónoma de Mexico, Mexico, Mexico. |
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| Abstract: | This paper provides macroscopic and histological evidence on the statistically significant protective effects of S3Pvac-phage vaccination against porcine cysticercosis and hydatidosis. The study included 391 rustically bred pigs (187 vaccinated and 204 controls). Vaccination significantly reduced the prevalence of cysticercosis by 61.7%. Vaccination also significantly reduced by 56.1% the prevalence of hydatidosis caused by Echinococcus granulosus in pigs. The presence of the vaccine epitopes in both cestodes is probably involved in the cross-protection observed. Increased inflammation was found in 5% of cysticerci recovered from controls, versus 24% from vaccinated pigs (P<0.01). Hydatid cysts were non-inflammatory in either group. Vaccination was effective to prevent one single disease, but it failed to prevent the simultaneous infections with both parasites in a same pig. The widening of the S3Pvac-phage vaccine protective repertoire to include hydatidosis is a convenient feature that should reduce the prevalence of two frequent zoonoses that affect rustic porcine breading with a single action. Thus, the costs of two different vaccination programs would be reduced to a single one with significant reduction in both zoonoses. |
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| Keywords: | Filamentous phages Vaccination Cysticercosis Hydatidosis Taenia solium Echinococcus granulosus |
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