Epinephrine and norepinephrine elevate 5′-monodeiodinase activity in rainbow trout liver slices |
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| Authors: | S E Brett J F Leatherland |
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| Institution: | (1) Department of Biomedical Sciences, Ontario Veterinary College, University of Guelph, Guelph, Ontario, N1G 2W1, Canada |
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| Abstract: | The 5′-monodeiodinase (5′-MDA) activity was measured in liver slices that were incubated for 3 hours with epinephrine (E)
or norepinephrine (NE) in order to examine the influence of these catecholamine hormones on the regulation of hepatic monodeiodination
of thyroxine (T4) in rainbow trout. Both E and NE induced a dose-dependent increase in 5′-MDA activity and in addition, E stimulated the release
of T3 into the medium. In liver slices taken from trout that had been treated with the β-adrenoceptor inhibitor propranolol, the
response to both E and NE was attenuated. The findings provide evidence of an action of these catecholamine hormones on the
peripheral regulation of T3 production, and suggest that the control operatesvia the β-adrenoceptors.
Corresponding author. |
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| Keywords: | catecholamine hormones thyroid metabolism Oncorhynchus mykiss hepatic enzyme propranolol β -adrenoceptor |
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