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| 犬瘟热病毒研究概况 | |
| 引用本文： | 胡嘉欣,温永俊,霍志云,武华,高维凡.犬瘟热病毒研究概况[J].动物医学进展,2012,33(6):134-139. |
| 作者姓名： | 胡嘉欣 温永俊 霍志云 武华 高维凡 |
| 作者单位： | 1. 沈阳农业大学,辽宁沈阳110866;中国农业科学院特产研究所,吉林长春130122 2. 中国农业科学院特产研究所,吉林长春,130122 3. 沈阳农业大学,辽宁沈阳,110866 |
| 摘 要： | 犬瘟热(CD)是由犬瘟热病毒(CDV)引起的一种急性、高度接触性传染病,流行范围广,发病率、致死率高,临床症状多样。CDV感染宿主广泛,所有日龄的犬都有可能感染。CDV属于副黏病毒科麻疹病毒属,有囊膜包裹的单股负链线性RNA病毒。CDV基因组编码6种蛋白:核衣壳(N)蛋白、磷(P)蛋白、基质膜(M)蛋白、融合(F)蛋白、血凝素(H)蛋白和大(L)蛋白。N、P和L蛋白与病毒复制有关;M蛋白与病毒的装配和出芽有关;F、H蛋白在病毒的侵染过程中起到关键作用。近年来,随着我国宠物业、毛皮经济养殖业的迅速发展,CD在我国的发病率有升高的趋势。论文对CDV分子生物学研究进展进行归纳总结。 |
| 关 键 词： | 犬瘟热病毒 分子生物学 致病机理 |
Progress on Canine Distemper Virus |
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| HU Jia-xin , WEN Yong-jun , HUO Zhi-yun , WU Hua , GAO Wei-fan.Progress on Canine Distemper Virus[J].Progress In Veterinary Medicine,2012,33(6):134-139. | |
| Authors: | HU Jia-xin WEN Yong-jun HUO Zhi-yun WU Hua GAO Wei-fan |
| Institution: | 1(1.Shenyang Agricultural University,Shenyang,Liaoning,110866,China;2.Division of Zoonosis,Institute of Special Economic Animal and Plant Sciences,Chinese Academy of Agricultural Sciences,Changchun,Jiling,130122,China) |
| Abstract: | Canine distemper(CD),an acute and highly contagious disease,caused by canine distemper virus(CDV).CD has epidemic wide range,high morbidity and mortality,and variety of clinical symptoms.CDV has wide host range,and all-day-old dogs can be infected.CDV is a member of Morbillivirus in Paramyxovirus family.CDV,an enveloped,linear single-stranded negative strand RNA virus.CDV genome encodes six protein: nuclearcapsid(N) protein,phosphorus(P),substrate membrane(M) protein,fusion(F) protein,hemagglutinin(H) protein and big(L) protein.N,P and L proteins are concerned with virus duplicate;M protein is associated with the virus of the assembly and budding;F,H proteins play an important role in virus infection process.With the rapid development of the pet industry and the fur farming industry,the incidence of CD was in a upward trend in China in recent years.In this paper recent progress in molecular biology of canine distemper virus was summarized,for the further study of canine distemper virus. |
| Keywords: | CDV molecular biology pathogenic mechanism |
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