Effect of calcitonin on adrenocorticotropic hormone secretion stimulated by corticotropin‐releasing hormone in the hen anterior pituitary |
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| Authors: | Hiroyuki NAKAYAMA Tetsuya TAKAHASHI Kaori NAKAGAWA‐MIZUYACHI Mitsuo KAWASHIMA |
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| Institution: | 1. The United Graduate School of Agricultural Science;2. Graduate School of Applied Biological Sciences, Gifu University, Gifu, Japan |
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| Abstract: | The presence of a receptor for calcitonin (CT) and the effect of chicken CT (cCT) on adrenocorticotropic hormone (ACTH) secretion stimulated by rat/human corticotropin‐releasing hormone (rhCRH) in the hen anterior pituitary were studied. The specific 125I]cCT binding component was present in the plasma membrane of hen anterior pituitary and this binding component had properties of a receptor which has binding specificity to cCT, reversibility, saturable binding, high affinity and limited capacity. When anterior pituitary cells were incubated in vitro, cCT increased the maximal secretion of chicken ACTH stimulated by rhCRH. These results suggest that CT may act directly on the anterior pituitary via its receptor binding and enhances the ACTH secretion by CRH. |
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| Keywords: | adrenocorticotropic hormone anterior pituitary calcitonin corticotropin‐releasing hormone hen |
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