Cytotoxic triterpene glycosides from the sea cucumber Pseudocolochirus violaceus |
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| Authors: | Zhang Shu-Yu Tang Hai-Feng Yi Yang-Hua |
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| Institution: | Research Center for Marine Drugs, College of Pharmacy, 2nd Military Medical University, Shanghai 200433, PR China. zhangshuyu77@163.com |
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| Abstract: | A new triterpene glycoside (1) along with the known intercedenside B (2) was isolated from the sea cucumber Pseudocolochirus violaceus. Glycoside 1 was elucidated as 3-O-{6-O-sodiumsulfate-3-O-methyl-beta-D-glucopyranosyl-(1-->3)-beta-D-xylopyranosyl-(1-->4)-beta-D-xylopyranosyl(1-->2)]-beta-D-quinovopyranosyl-(1-->2)-4-O-sodiumsulfate-beta-D-xylopyranosyl}-16beta-acetoxy-holosta-7, 24-diene-3beta-ol on the basis of extensive spectral studies and chemical evidence. Both the glycosides exhibited significant cytotoxicity against cancer cell lines MKN-45 and HCT-116. |
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| Keywords: | Pseudocolochirus violaceus Triterpene glycoside Cytotoxicity |
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