The lesional changes and pathogenesis in the kidney in african swine fever |
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| Authors: | J Hervás J C Gómez-Villamandos A Méndez L Carrasco M A Sierra |
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| Institution: | (1) Dpto. de Anatomía Patológica, Facultad de Veterinaria, Avda. Medina Azahara 9, 14005 Córdoba, Spain |
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| Abstract: | African swine fever is a viral haemorrhagic disease of pigs which has been used as a model for the study of viral haemorrhagic diseases in man. The acute course of the disease is characterized by acute proliferative glomerulonephritis, with viral replication in mesangial cells and occasional focal necrosis of the renal tubular system; hyperplasia of the collecting ducts is associated with evident virus replication. Haemorrhages have been attributed to endothelial dysfunction, aggravated by virus replication in endothelial cells in the final stages of the disease. The renal interstitium displays intense oedema and an infiltrate largely composed of macrophages. Virus replication has also been observed in fibroblasts and in the smooth0muscle cells of arterioles and venules.In subacute-chronic forms of the disease, various types of glomerulonephritis are observed, ranging from mesangial proliferative glomerulonephritis to focal and segmental hyalinosis associated with immune-mediated phenomena. No striking changes are reported in the renal tubular system. Interstitial haemorrhages are associated with diapedesis due to immunologically mediated events. The interstitium has also been found to contain a lymphohistiocytic infiltrate with abundant plasma cells. No evidence has been reported of viral replication in any cell population.Abbreviations ASF
African swine fever
- ASFV
African swine fever virus
- C
complement component
- DNA
deoxyribonucleic acid
- HAD50
50% haemoadsorbing doses
- Ig
immunoglobulin
- MPS
mononuclear phagocytic system
- PAS
periodic acid-Schiff reagent |
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| Keywords: | African swine fever kidney pathology pigs virus |
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