| 禽流感病毒非结构蛋白NS1在感染和免疫中的作用 |
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| 引用本文： | 路冰,陈化兰,包红梅,王秀荣,张秀英.禽流感病毒非结构蛋白NS1在感染和免疫中的作用[J].中国畜牧兽医,2011,38(5):182-185. |
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| 作者姓名： | 路冰 陈化兰 包红梅 王秀荣 张秀英 |
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| 作者单位： | 1. 东北农业大学,黑龙江哈尔滨 150030;2. 中国农业科学院哈尔滨兽医研究所,黑龙江哈尔滨 150001 |
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| 摘 要： | NS1蛋白(non-structural 1 protein)是目前发现的唯一的禽流感病毒非结构蛋白,它是一种多功能调节蛋白,对病毒的感染、复制和毒力具有重要的作用;该蛋白主要通过颉颃宿主干扰素及肿瘤坏死因子,抑制宿主蛋白的合成及调控感染细胞的凋亡来实现其作用。作者综述了NS1蛋白生物学特性及其在感染和免疫中作用的研究进展,为进一步研究NS1蛋白的特性及临床应用提供了参考。
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| 关 键 词： | 禽流感 非结构蛋白 生物学特性 |
| 收稿时间： | 2010-10-28 |
Roles of Avian Influenza Virus Non-structural 1 Protein in Infection and Immunity |
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| LU Bing,CHEN Hua-lan,BAO Hong-mei,WANG Xiu-rong,ZHANG Xiu-ying.Roles of Avian Influenza Virus Non-structural 1 Protein in Infection and Immunity[J].China Animal Husbandry & Veterinary Medicine,2011,38(5):182-185. |
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| Authors: | LU Bing CHEN Hua-lan BAO Hong-mei WANG Xiu-rong ZHANG Xiu-ying |
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| Institution: | 1. Northeast Agricultural University,Harbin 150030,China;2. Harbin Veterinary Research Institute,Chinese Academy of Agricultural Sciences,Harbin 150001,China |
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| Abstract: | NS1 (non-structural 1) protein is the unique non-structural protein found in avian influenza virus. It is a kind of multifunctional regulatory protein which plays a vital role in virus infection,replication and virulence. Its main function is antagonizing the host interferon and tumor necrosis factor,production inhibiting host protein synthesis as well as regulating apoptosis of infected cells. This paper reviews the latest research on the biological characteristics of NS1 protein and its role in infection and immunity which provide a reference for further research on NS1 protein’s characteristics and clinical application. |
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| Keywords: | avian influenza non-structural protein biological characteristics |
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