| 穿心莲内酯纳米混悬剂的制备与评价 |
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| 引用本文： | 刘锦妮,郝素旗,陈潇钦,叶兆伟,吴海港.穿心莲内酯纳米混悬剂的制备与评价[J].中国兽药杂志,2021,55(1):41-46. |
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| 作者姓名： | 刘锦妮 郝素旗 陈潇钦 叶兆伟 吴海港 |
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| 作者单位： | 信阳农林学院牧医工程学院;信阳市兽药新制剂研发与创制工程技术研究中心,,,,信阳农林学院牧医工程学院 |
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| 基金项目： | 河南省高等学校重点科研项目(17A230006)； |
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| 摘 要： | 为优选穿心莲内酯纳米混悬剂的制备工艺并进行初步评价,试验以二甲基亚砜为溶剂、水为反溶剂,采用反溶剂法制备穿心莲内酯纳米混悬剂(ANDRO-NS),以得率为指标,通过单因素试验和正交试验优化了ANDRO-NS的制备工艺,并进行验证试验,采用透射电镜、激光粒径仪对所制备的纳米混悬剂进行表征。结果显示:1%吐温-80混和0.05%泊洛沙姆为稳定剂,药物浓度为40 mg/mL,反溶剂和溶剂的体积比为20,搅拌速率为1400 r/min,搅拌时间为80 min,制得的ANDRO-NS平均粒径为568.51±13.74 nm,粒径合适,稳定性良好。试验表明,采用反溶剂沉淀法制备的ANDRO-NS工艺简单,值得进一步研究。
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| 关 键 词： | 穿心莲内酯 纳米混悬剂 反溶剂沉淀法 正交试验 反溶剂法 |
| 收稿时间： | 2020/8/21 0:00:00 |
| 修稿时间： | 2020/12/30 0:00:00 |
Preparation of Andrographolide Nanosuspensions by anti-solvent method |
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| LIU Jin-ni,HAO Su-qi,CHEN Xiao-qin,YE Zhao-wei,WU Hai-gang.Preparation of Andrographolide Nanosuspensions by anti-solvent method[J].Chinese Journal of Veterinary Drug,2021,55(1):41-46. |
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| Authors: | LIU Jin-ni HAO Su-qi CHEN Xiao-qin YE Zhao-wei WU Hai-gang |
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| Institution: | College of Animal Husbandry and medical engineering, Xinyang Agriculture And Forestry University,,,,, |
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| Abstract: | In order to optimize the preparing process of Andrographolide nanosuspension(ANDRO-NS)and evaluate it preliminarily,anti-solvent recrystallization method was used to prepare ANDRO-NS with dimethyl sulfoxide as solvent and water as anti-solvent.Using yield rate as indicator,single factor test and orthogonal test were adopted and verification test was conducted.The ANDRO-NS were characterized by transmission electron microscopy and laser particle size analyzer.The results showed that Tween-80 and F68 were used as stabilizer and co-stabilizer respectively.The ratio of Tween-80 to F68 was 20∶1,solvent-anti-solvent volume ratio was 1∶20,the concentration of the drug was 40 mg/mL,the stirring speed was 1400 r/min,and the stirring time was 80 minutes.The average size of prepared ANDRO-NS was 568.51±13.74 nm,which was suitable and stability.In a conclusion,using the anti-solvent precipitation method to prepared ANDRO-NS was simple and safe,and this method was valuable to study further. |
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| Keywords: | Andrographolide nanosuspensions anti-solvent precipitation method Orthogonal test Antisolvent method |
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