| 丙硫苯咪唑在奶山羊体内药代动力学研究 |
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| 引用本文： | 赖国旗.丙硫苯咪唑在奶山羊体内药代动力学研究[J].四川农业大学学报,1991,9(3):464-468. |
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| 作者姓名： | 赖国旗 |
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| 作者单位： | 四川农业大学兽医学系 雅安 |
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| 摘 要： | 本文报道用高压液相色谱法研究了奶山羊一次口服丙硫苯咪唑粉剂(20mg/kg)后,血中丙硫苯咪唑及其代谢物—亚砜和砜的药代动力学规律。测定条件YWG-80μm,150×4.6mm不锈钢柱;流动相:正已烷—乙醇—乙晴(360:50:0.26V/V/V);紫外检测波长:292nm。甲苯咪唑作内标。主要动力学参数:亚砜和砜的T1/2、Tmax、Cmax、AUC分别为:10.98(hr);20.48(hr),12.01(hr);20.72(hr);50.11(μg/ml);1.79(μg/ml);173.18(μg/ml.hs);106.56(μg/ml.hr)
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| 关 键 词： | 动力学[31BC] 代谢[45EG] 高压[32DA] 甲苯[34G] 砜[34G] |
STUDIES ON PHARMACOKINETICS OF ALBENDAZOLE IN MILKING GOAT |
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| Lai Guoqi.STUDIES ON PHARMACOKINETICS OF ALBENDAZOLE IN MILKING GOAT[J].Journal of Sichuan Agricultural University,1991,9(3):464-468. |
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| Authors: | Lai Guoqi |
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| Abstract: | This paper reports on the pharmacokinetics of albendazole and its main metabolites-sulfoxide and sulfone in serum of milking goat given albendazole as a powder at a does rate of 20mg/kg weight by high performance liquid chromatographic method (HPLC). YWG-80 was chosen as solid phase and the mobile phase consisted of hexane ethanol acetonitrile (360:50:0.26v/v/v). The wavelenght of UV detector was 292nm. Mebendazole was used as an internal standard. The major parameters were respectively T1/2k、Tmax、Cmax、AUC of sulfoxide and sulfone are: 10.98(hr)、20.48(hr)、12.01(hr)、20.72(hr)、5.11(μg/ml)、1.79(μg/ml); 173.18(μg/ml.hr)、106.56(μg/ml.hr). |
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| Keywords: | DYNAMICS METABOLISN HIGH PRESSSURE METHYLBENZENE SULFONE |
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