| 三苯基锡对褐菖鮋精巢发育的影响及其作用机制 |
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| 引用本文： | 张纪亮,熊建利,朱文文,孙平,郭黛健.三苯基锡对褐菖鮋精巢发育的影响及其作用机制[J].海洋渔业,2011,33(3). |
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| 作者姓名： | 张纪亮 熊建利 朱文文 孙平 郭黛健 |
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| 作者单位： | 1. 河南科技大学动物科技学院,洛阳,471003
2. 洛阳师范学院,洛阳,471022 |
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| 基金项目： | 国家自然科学基金(20777061)资助 |
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| 摘 要： | 三丁基锡(tributyltin,TBT)和三苯基锡(triphenyltin,TPT)广泛应用于海洋船只防污涂料。但相对于TBT,对TPT的毒性研究还很少。本实验以海洋经济鱼类褐菖鲉(Sebastiscus marmoratus)为对象,研究环境水平TPT对精巢发育的影响。研究发现,TPT降低精巢的精子数目和密度,增加精小叶间隙脂滴数量和精巢总脂质水平。另外,TPT降低精巢睾酮酯化水平,增加游离睾酮水平,降低游离17β-雌二醇水平。TPT对精巢发育的抑制可能与精小叶间隙脂质水平的增加及精巢17β-雌二醇水平的降低有关。实验结果为全面了解TPT产生鱼类生殖毒性效应、途径和机制提供了新的重要资料。环境水平的TPT能够抑制精巢的发育,而且毒性要高于TBT。这些结果为海洋环境政策的制定和评估有机锡污染对海洋鱼类资源的影响提供了重要的依据。
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| 关 键 词： | 三苯基锡 褐菖鮋 精巢 作用机制 |
Effect of triphenyltin on the testicular development in Sebastiscus marmoratus and its action mechanism |
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| ZHANG Ji-liang,XIONG Jian-li,ZHU Wen-wen,SUN Ping,GUO Dai-jian.Effect of triphenyltin on the testicular development in Sebastiscus marmoratus and its action mechanism[J].Marine Fisheries,2011,33(3). |
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| Authors: | ZHANG Ji-liang XIONG Jian-li ZHU Wen-wen SUN Ping GUO Dai-jian |
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| Institution: | ZHANG Ji-liang1,XIONG Jian-li1,ZHU Wen-wen1,SUN Ping1,GUO Dai-jian2(1.College of Animal Science and Technology,Henan University of Science and Technology,Luoyang 471003,China,2.Luoyang Normal University,Luoyang 471022,China) |
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| Abstract: | The worldwide use of two triorganotin compounds,triphenyltin(TPT) and tributyltin(TBT) as fungicides and pesticides in agricultural activities and as ingredients of antifouling paints,have caused the contamination of aquatic environment globally.Much attention have been paid to pollution by TBT due to the fact that TBT dominated over TPT in usage amount as antifouling paint ingredients.Recently,an increasing number of studies reported unexpectedly high levels of TPT in fishes around the world,because TPT co... |
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| Keywords: | Triphenyltin Sebastiscus marmoratus testis mechanism |
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