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Immunosuppressant Effect of Long Term and Subtherapeutic Chlortetracycline in Broiler |
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| Authors: | TONG Jian-ming ZHANG Ri-jun SA Ren-na PAN Shu-yuan HUANG Yan |
| Institution: | 1. Institute of Animal Science, Chinese Academy of Agricultural Sciences, Beijing 100081 , China 2. College of Animal Science and Technology, CAU Beijing 100094 3. College of Basal Science and Technology, CAU, Beijing 100094 ,P. R. China |
| Abstract: | Experiments were conducted with 270 Abore Acre male broilers to study the influence of dietary chlortetracycline (CTC) on the bursal, thymus and spleen weight index and T, B cell proliferation and antibody responses of broilers. Results show that 50mg/kg CTC had no significant inhibitory effect on thymus and spleen weight index, and T, B cell proliferation of broilers at 21 days old. 150mg/kg CTC had significant inhibitory effect on bursal, thymus and spleen, and T, B cell proliferation (P＜0.05). Dietary CTC had a direct inhibitory effect on lymphocyte proliferation in vitro. 50mg/kg and 150mg/kg CTC had a significant inhibitory effect on the antibody responses to BSA (P＜0.01). Results demonstrated that subtherapeutic and long term CTC had significant inhibitory effects on immune organs and antibody response. The immunosuppressant effect became higher when the level of CTC increased. 150mg/kg CTC increased the growth rate of broilers significantly. |
| Keywords: | Immunosupperession Cholrtetracycline Broiler |
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