Effect of recombinant human granulocyte colony stimulating factor on lymphocyte blastogenesis in healthy dogs |
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| Authors: | Hasegawa T Inomata T |
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| Institution: | Veterinary Teaching Hospital, Faculty of Agriculture, Miyazaki University, Gakuen-Kibanadai, Japan. |
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| Abstract: | Effects of recombinant human granulocyte colony-stimulating factor (rhG-CSF) on the number and blastogenesis of lymphocytes were evaluated in clinically healthy dogs treated subcutaneously with rhG-CSF at a dose of 2.5 microg/kg for 3 days. Significant increases in the number of leukocytes and segmented neutrophils were observed after the administration of rhG-CSF. The number of lymphocytes also increased on days 1 and 2 after the treatment. Activities of phytohemagglutinin, concanavalin A, and pokeweed mitogen-induced lymphocyte blastogenesis (LB) were augmented to twice the pretreatment levels by the administration of rhG-CSF. These results suggested that administration of rhG-CSF activated lymphocyte functions such as LB in healthy dogs. |
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