| 亚硒酸钠在肉鸡体内药代动力学的研究 |
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| 引用本文： | 李元新,刘来利,王必成,张鹏岳.亚硒酸钠在肉鸡体内药代动力学的研究[J].畜牧兽医杂志,2012,31(4):14-15. |
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| 作者姓名： | 李元新 刘来利 王必成 张鹏岳 |
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| 作者单位： | 甘肃省畜牧兽医研究所,甘肃平凉,744000 |
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| 基金项目： | 甘肃省科技计划资助项目;项目 |
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| 摘 要： | 实验研究了30日龄肉鸡单次肌注(0.6mg/Kg)亚硒酸钠注射液后不同时间采血,用流动注射氢化物发生原子吸收光谱法测定血硒浓度,经微机处理得出血硒浓度及药动学参数,血硒浓度-时间曲线符合一级吸收一室开放模型,最佳药时方程:C=100.2001(e-0.0197t-e-1.6428t)。主要药动学参数:t1/2Ka为0.421 9h,t1/2Ke为35.121 5h,tp为3.312 4h,Cmax为93.986 5μg/L,AUC为5 025.314 9(μg/L).h。根据单剂量给药参数,计算出多剂量给药参数。
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| 关 键 词： | 亚硒酸钠 药物动力学 肉鸡 |
Study on Pharmacokinetics of Sodium Selenite by in Vivo Intramuscular Injection in Broiler |
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| LI Yuan-xin,LIU Lai-li,WANG Bi-cheng,ZHANG Peng-yue.Study on Pharmacokinetics of Sodium Selenite by in Vivo Intramuscular Injection in Broiler[J].Journal of Animal Science and Veterinary Medicine,2012,31(4):14-15. |
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| Authors: | LI Yuan-xin LIU Lai-li WANG Bi-cheng ZHANG Peng-yue |
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| Institution: | ( Gansu Institute of Animal Science and Veterinary Medicine, P ing liang 744000, China) |
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| Abstract: | Through single intramuscular injection of sodium selenite 0.6 mg/kg, blood samples were collected in different time and selenium concentration was measured using hydride generation atomic absorption spectrometry, blood selenium con- centration and pharmacokinetics parameter were obtained after treated by computer. The curve of blood selenium and time fit- ted the three-compartment open model, pharmacokinetic equation： C = 100. 2001 （e^-0.0197t·-e^-1.6428t）. main parameters： the half-life absorption （T1/2 Ka） was 0. 4219hrs, the time of reaching maximum concentration （Tp） was 3. 3124hrs, the area under the curve （AUC） was （ug/L）· h,and the volume of distribution（Vd） was 2. 722L/kg. The parameters of multiple doses were calculated for clinic treat based on the kinetic parameters of the single dose. |
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| Keywords: | sodium selenite pharmacokinetics broiler |
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