| 归芪益母汤耐缺氧及抗氧化作用 |
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| 引用本文： | 许小琴,韦旭斌,刘学忠,李金贵,胡仲明,柳巨雄,王治,张玉国.归芪益母汤耐缺氧及抗氧化作用[J].中国兽医学报,2005,25(2):208-210. |
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| 作者姓名： | 许小琴 韦旭斌 刘学忠 李金贵 胡仲明 柳巨雄 王治 张玉国 |
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| 作者单位： | 1. 吉林大学,畜牧兽医学院,吉林,长春,130062
2. 扬州大学,畜牧兽医学院,江苏,扬州,225009 |
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| 基金项目： | 解放军总后勤部军需部资助项目(JX990119) |
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| 摘 要： | 归芪益母汤经水提醇沉制成注射液 ,给小鼠经腹腔注射给药 ,进行常压缺氧、减压缺氧、化学法缺氧和抗氧化试验 ,探讨了归芪益母汤对小鼠耐缺氧和抗氧化能力的影响。结果表明 ,归芪益母汤注射液显著延长了缺氧小鼠的存活时间 (P<0 .0 1 ) ,其中常压缺氧存活时间延长 1 1 0 .2 1 %,减压缺氧存活时间延长 76 .4 8%,化学法缺氧存活时间延长2 4 0 .87%,提示归芪益母汤能够提高小鼠的耐缺氧能力。抗氧化方面 ,体内试验表明 ,其能显著降低小鼠因急性缺氧再暴露所引起的 MDA的产生 (P<0 .0 1 ) ;体外试验表明 ,能拮抗 H2 O2 诱导的溶血 ,抑制超氧离子 (O- 2 )生成
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| 关 键 词： | 归芪益母汤 中药复方 耐缺氧作用 抗氧化作用 小鼠 |
| 文章编号： | 1005-4545(2005)02-0208-03 |
| 修稿时间： | 2004年2月24日 |
Effect of Gui Qi Yimu Decoction on Hypoxia Tolerance and Anti-oxidation in Mice |
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| XU Xiao-qin,WEI Xu-bin,LIU Xue-zhong,LI Jin-gui,HU Zhong-ming,LIU Ju-xiong,WANG Zhi,ZHANG Yu-guo.Effect of Gui Qi Yimu Decoction on Hypoxia Tolerance and Anti-oxidation in Mice[J].Chinese Journal of Veterinary Science,2005,25(2):208-210. |
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| Authors: | XU Xiao-qin WEI Xu-bin LIU Xue-zhong LI Jin-gui HU Zhong-ming LIU Ju-xiong WANG Zhi ZHANG Yu-guo |
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| Institution: | XU Xiao-qin~1,WEI Xu-bin~1,LIU Xue-zhong~2,LI Jin-gui~2,HU Zhong-ming~1,LIU Ju-xiong~1,WANG Zhi~1,ZHANG Yu-guo~1 |
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| Abstract: | To explore the effects of Gui Qi Yimu decoction on hypoxia tolerance and anti-oxidation,the aqueous extracts of Gui Qi Yimu decoction were once-alcohol deposited and made into injection for this study.The experimental mice were injected intraperitoneally to conduct normobaric hypoxia,hypobaric hypoxia,chemical hypoxia and anti-oxidation experiments.The results showed that Gui Qi Yimu injection significantly prolonged the survival time of experimental mice(P<0.01).The survival time in the mice treated with normobaric hypoxia prolonged by 110.21%,76.48% in the mice treated with hypobaric hypoxia and 240.87% in the mice treated with chemical hypoxia.This suggested Gui Qi Yimu decoction may enhance the ability of hypoxia tolerance.In the aspect of anti-oxidation,the results in vivo showed,the Gui Qi Yimu injection could significantly decrease the synthesis of serum MDA induced by acute hypoxia and re-expose treating(P<0.01).The data in vitro indicated that the hemolysis induced by H_2O_2 and production of O~-_2 could be antagonized or inhibited by Gui Qi Yimu decoction. |
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| Keywords: | Gui Qi Yimu decoction Chinese herbal formula hypoxia tolerance anti-oxidation mouse |
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