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| 苯甲酸雌二醇在奶牛体内的药物动力学 | |
| 引用本文： | 黄冻,李引乾,张海亮,梅雪洁,庞利娜,杨烨,韩冰.苯甲酸雌二醇在奶牛体内的药物动力学[J].西北农业学报,2009,18(3):29-32. |
| 作者姓名： | 黄冻 李引乾 张海亮 梅雪洁 庞利娜 杨烨 韩冰 |
| 作者单位： | 1. 西北农林科技大学,动物医学院,陕西杨凌,712100 2. 国营西安草滩制药厂,陕西西安,710021 3. 陕西西乡长江动物药品有限责任公司,陕西西乡,723500 |
| 摘 要： | 分析苯甲酸雌二醇在奶牛体内的药物代谢动力学过程.试验前对奶牛进行摘除卵巢手术,术后30 d单剂量肌肉注射不孕奶牛催乳注射液(苯甲酸雌二醇+黄体酮),216 h内不同时间17次颈静脉采血,用放射免疫法(RIA)测定血清中雌二醇浓度.结果表明,雌二醇在奶牛体内的药物动力学配置符合有吸收因素的二室开放模型,其药时曲线最佳方程为:C=283.773e-0.0326t+136.748e-0.0133t-420.521e-0.0770t.消除半衰期(t1/2)为(52.232±1.383) h;药时曲线下面积(AUC)为(13525.940±288.114) pg/(mL·h);达峰时间(Tp)为(22.025±0.427) h,达峰浓度(Cp)为(165.385±3.120) pg/mL.试验结果显示,苯甲酸雌二醇在奶牛体内分布广泛,吸收和消除较慢. |
| 关 键 词： | 苯甲酸雌二醇 奶牛 药物动力学 |
| 收稿时间： | 2008/11/3 0:00:00 |
| 修稿时间： | 2009/1/5 0:00:00 |
The Pharmacokinetics of Estradiol Benzoate in Cows |
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| HUANG Dong,LI Yinqian,ZHANG Hailiang,MEI Xuejie,PANG Lin,YANG Ye and HAN Bing.The Pharmacokinetics of Estradiol Benzoate in Cows[J].Acta Agriculturae Boreali-occidentalis Sinica,2009,18(3):29-32. | |
| Authors: | HUANG Dong LI Yinqian ZHANG Hailiang MEI Xuejie PANG Lin YANG Ye and HAN Bing |
| Institution: | College of Veterinary Medicine, Northwest A&F University, Yangling Shaanxi 712100, China;College of Veterinary Medicine, Northwest A&F University, Yangling Shaanxi 712100, China;College of Veterinary Medicine, Northwest A&F University, Yangling Shaanxi 712100, China;College of Veterinary Medicine, Northwest A&F University, Yangling Shaanxi 712100, China;College of Veterinary Medicine, Northwest A&F University, Yangling Shaanxi 712100, China;State-owned Xi''an Caotan Drug Manufactory, Xi''an Shaanxi 710021, China;Shaanxi Xixiang Changjiang Animal Drugs Co., LTD, Xixiang Shaanxi 723500, China |
| Abstract: | The pharmaco kinetic process of estradiol bemzoate(EB) was analysed so asto provide a the oretical basis for rational use of drug in veterinary clinic.Four cows after ovariectomy were treated with a single dosage of injection of progesterone and estradiol benzoate by intramuscular injection.Blood samples were collected from jugular vein for 17 times in various time within 216 h.Then the serum concentration was measured by the Radio-immunoassay(RIA).The result showed that the two-compatrment model with absorption factor adequately described concentrations of estradiol in serum disposition and the best concentratron-time equation was C=283.773e-0.0326t+136.748e-0.0133t-420.521e-0.0770t.The main pharmacokinetics parameters were as follow:the half-life t1/2 was(52.232±1.383)h;AUC was(13525.940±288.114)pg/(mL·h);Tp was(22.025±0.427)h,and Cp was(165.385±3.120)pg/mL.It was slow forest radiolto absorb and eliminate in cow,and the distribution of estradiol benzoate was abroad. |
| Keywords: | Estradiol benzoate Cow Pharm acokinetics |
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