| 黑蜂蜂胶免疫活性和体内抗肿瘤研究 |
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| 引用本文： | 孙小英,邹玉,王涛,王魁源,罗志文,李春丰.黑蜂蜂胶免疫活性和体内抗肿瘤研究[J].安徽农业科学,2017,45(9). |
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| 作者姓名： | 孙小英 邹玉 王涛 王魁源 罗志文 李春丰 |
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| 作者单位： | 佳木斯大学生命科学学院,黑龙江佳木斯,154007;佳木斯大学生命科学学院,黑龙江佳木斯,154007;佳木斯大学生命科学学院,黑龙江佳木斯,154007;佳木斯大学生命科学学院,黑龙江佳木斯,154007;佳木斯大学生命科学学院,黑龙江佳木斯,154007;佳木斯大学生命科学学院,黑龙江佳木斯,154007 |
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| 基金项目： | 黑龙江省2016年佳木斯大学研究生科技创新项目 |
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| 摘 要： | 目的]观察东北黑蜂蜂胶醇提取物对昆明鼠免疫活性的影响和肿瘤抑制率。方法]通过动物体内试验,制备H22模型小鼠,计算黑蜂蜂胶提取物肿瘤抑制率,测定单核-巨噬细胞碳廓清的吞噬指数。结果]东北黑蜂蜂胶醇提取物各组的吞噬指数、瘤重与阴性对照组比较,具有统计学意义(P0.05),说明东北黑蜂蜂胶醇提取物能够提高H22小鼠的免疫活性,对肿瘤的生长在一定程度上有很强的抑制作用,东北黑蜂蜂胶的乙醇提取物抗肿瘤作用显著。结论]该研究为蜂产品进一步走向医疗领域特别是治疗癌症提供理论支持。
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| 关 键 词： | 东北黑蜂 蜂胶醇提取物 昆明小鼠 免疫活性 抗肿瘤 |
Study on Immune Activity and Antitumor Activity of Apis mellifera Propolis |
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| SUN Xiao-ying,ZOU Yu,WANG Tao,WANG Kui-yuan,LUO Zhi-wen,LI Chun-feng.Study on Immune Activity and Antitumor Activity of Apis mellifera Propolis[J].Journal of Anhui Agricultural Sciences,2017,45(9). |
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| Authors: | SUN Xiao-ying ZOU Yu WANG Tao WANG Kui-yuan LUO Zhi-wen LI Chun-feng |
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| Abstract: | Objective] The research aimed to observe the effect of alcohol extract of northeast Apis mellifera propolis on immune activity and tumor inhibition rate of Kunming mice.Method] H22 model mice were prepared by in vivo animal test.The tumor inhibition rate of Apis mellifera propolis extract was calculated and the phagocytic index of mononuclear macrophages was measured.Result] The phagocytic index and tumor weight of the Apis mellifera propolis extract were significantly higher than those of the negative control group (P<0.05),which indicated that the extract of northeastern Apis mellifera propolis could improve the immunological activity of H22 mice and had a strong inhibitory effect on the growth of tumor.The ethanol extract of northeastern Apis mellifera propolis had significant anti-tumor effect.Conclusion] The study provides theoretical support for the further development of bee products in the medical field,especially in the treatment of cancer. |
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| Keywords: | Apis mellifera Alcohol extract of propolis Kunming mice Immunological activity Antitumor |
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