Antibacterial bisabolane-type sesquiterpenoids from the sponge-derived fungus Aspergillus sp |
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| Authors: | Li Dan Xu Ying Shao Chang-Lun Yang Rui-Yun Zheng Cai-Juan Chen Yi-Yan Fu Xiu-Mei Qian Pei-Yuan She Zhi-Gang de Voogd Nicole J Wang Chang-Yun |
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| Institution: | Key Laboratory of Marine Drugs, Ministry of Education, School of Medicine and Pharmacy, Ocean University of China, Qingdao 266003, China. |
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| Abstract: | Four new bisabolane-type sesquiterpenoids, aspergiterpenoid A (1), (-)-sydonol (2), (-)-sydonic acid (3), and (-)-5-(hydroxymethyl)-2-(2',6',6'-trimethyltetrahydro-2H- pyran-2-yl)phenol (4) together with one known fungal metabolite (5) were isolated from the fermentation broth of a marine-derived fungus Aspergillus sp., which was isolated from the sponge Xestospongia testudinaria collected from the South China Sea. Four of them (1-4) are optically active compounds. Their structures and absolute configurations were elucidated by using NMR spectroscopic techniques and mass spectrometric analysis, and by comparing their optical rotations with those related known analogues. Compounds 1-5 showed selective antibacterial activity against eight bacterial strains with the MIC (minimum inhibiting concentrations) values between 1.25 and 20.0 μM. The cytotoxic, antifouling, and acetylcholinesterase inhibitory activities of these compounds were also examined. |
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| Keywords: | bisabolane-type sesquiterpenoid antibacterial sponge-derived fungus Aspergillus sp |
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