| 香豆素-3-羧酸的合成·晶体结构与抗菌活性 |
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| 引用本文： | 苗延青,秦蓓,张小清,刘春叶.香豆素-3-羧酸的合成·晶体结构与抗菌活性[J].安徽农业科学,2010,38(35):20019-20020. |
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| 作者姓名： | 苗延青 秦蓓 张小清 刘春叶 |
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| 作者单位： | 西安医学院药学院,陕西西安,710068;西安医学院药学院,陕西西安,710068;西安医学院药学院,陕西西安,710068;西安医学院药学院,陕西西安,710068 |
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| 基金项目： | 陕西省卫生厅专项科研计划项目 |
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| 摘 要： | 目的]合成香豆素-3-羧酸,测定其晶体结构,并研究其抗菌活性。方法]采用X-射线单晶衍射法测定该化合物的晶体结构;采用琼酯扩散法测定其抗菌活性。结果]香豆素-3-羧酸晶体属单斜晶系,空间群P21/n,a为11.342 0（11）nm,b为5.521 2（5）nm,c为13.808 8（14）nm,β为106.31（1）°,V为829.45（14）nm3,Z为4,Dx为1.510 mg/m3,F（000）为392。晶体中只有1种分子间氢键,2分子香豆素-3-羧酸通过此氢键形成二聚体,作为构成此晶体的基本结构单元。香豆素-3-羧酸对柠檬色葡萄球菌、普通变形杆菌、产气肠杆菌、绿脓杆菌、大肠杆菌都有较好的抗菌活性。结论]该研究为香豆素-3-羧酸在抗菌活性方面的应用提供了依据。
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| 关 键 词： | 香豆素-3-羧酸 晶体结构 抗菌活性 |
Synthesis,Character and Antibacterial Activities of 3-carboxy Coumarin |
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| Institution: | MIAO Yan-qing et al(Department of Pharmacology Xi＇an Medical University,Xi＇an,Shanxi 710068) |
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| Abstract: | Objective] To synthesize 3-carboxy coumarin(C10H6O4,Mr=190.15) and study the antibacterial activity of the compound.Method] The crystal structure was determined by single crystal X-ray diffraction,the antibacterial activity of 3-Carboxy coumarin were determinect by diffusion methocl.Result] The crystal was monoclinic,space group P21/n with a=11.342 0(11) nm,b=5.521 2(5)nm,c=13.808 8(14)nm,β=106.31(1)°;the antibacterial activity of 3-carboxy coumarin were determined by agar diffusion method.V=829.45(14) nm3,Z=4,Dx=1.510 mg/m3,F(000)=392.The results of crystal structure determination showed that there was a single intramolecular H bond.In the crystal,dimers,connected by feeble hydrogen bonds,were found to be the basic units.The antibacterial tests indicated the compound had a remarkable effect against S.taphylococcus citreus,P roteus vulgaris,E nterobacter aerogenes,P seudomonas aeruginosa,E scherichia coli.Conclusion] It provided a basis for the 3-carboxy coumarin's application in antibacterial activity. |
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| Keywords: | 3-carboxy coumarin Crystal structure Antibacterial activities |
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