| 豆类丝核菌次级代谢产物与阿霉素在小鼠体内联合抑瘤作用 |
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| 引用本文： | 杨萍,贾红勋,安加俊,杨鸣琦.豆类丝核菌次级代谢产物与阿霉素在小鼠体内联合抑瘤作用[J].西北农业学报,2009,18(6):34-38. |
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| 作者姓名： | 杨萍 贾红勋 安加俊 杨鸣琦 |
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| 作者单位： | 杨萍(西北农林科技大学,动物医学院,陕西杨凌,712100;咸阳市动物疫病预防控制中心,陕西咸阳,712000);贾红勋,安加俊(咸阳市动物疫病预防控制中心,陕西咸阳,712000);杨鸣琦(西北农林科技大学,动物医学院,陕西杨凌,712100) |
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| 基金项目： | 国家自然科学基金资助项目 |
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| 摘 要： | 探讨豆类丝核菌次级代谢产物与阿霉素(ADR)对小鼠肉瘤的体内联合抑制作用.建立小鼠肉瘤S180动物模型,分别用豆类丝核菌次级代谢产物、阿霉素、两药联合进行处理.计算抑瘤率、脾指数,测定小鼠T淋巴细胞活化指数、腹腔巨噬细胞吞噬活性,并对小鼠进行病理学观察.试验结果表明,两药联合能提高抑瘤率,次级代谢产物能显著提高小鼠的脾指数,使T淋巴细胞活化指数升高,腹腔巨噬细胞吞噬活性增强,同时能使瘤细胞密度降低,瘤组织出现大量变性坏死.豆类丝核菌次级代谢产物具有免疫增强作用,该产物与阿霉素联合对抑制小鼠移植性肉瘤S180具有相加作用.
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| 关 键 词： | 豆类丝核菌 苦马豆素 阿霉素 肉瘤 抑瘤作用 |
| 收稿时间： | 2009/8/12 0:00:00 |
| 修稿时间： | 2009/9/12 0:00:00 |
Co-inhibiting-tumor Effects of Secondary Metabolites of Rhizotonia leguminicola and Adriamycin for Mice in Vivo |
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| YANG Ping,JIA Hongxun,AN Jiajun and YANG Mingqi.Co-inhibiting-tumor Effects of Secondary Metabolites of Rhizotonia leguminicola and Adriamycin for Mice in Vivo[J].Acta Agriculturae Boreali-occidentalis Sinica,2009,18(6):34-38. |
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| Authors: | YANG Ping JIA Hongxun AN Jiajun and YANG Mingqi |
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| Institution: | College of Veterinary Medicine, Northwest A&F University, Yangling Shaanxi 712100, China;Xianyang Animal Disease Control Center, Xianyang Shaanxi 712000, China;Xianyang Animal Disease Control Center, Xianyang Shaanxi 712000, China;Xianyang Animal Disease Control Center, Xianyang Shaanxi 712000, China;College of Veterinary Medicine, Northwest A&F University, Yangling Shaanxi 712100, China |
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| Abstract: | The secondary metabolites of Rhizoctonia leguminicola and adriamycin were administrated in S_(180) tumor-bearing mice respectively and cooperatively, to investigate the co-inhibiting-tumor and immunoregulation effects of the two medicines. Tumor-inhibitory rate, spleen index, stimulation index of T Lymphocyte and phagocyte ability of Peritoneal Macrophages were tested, moreover, pathological changes were observed. The results showed that the two medicines have co-inhibiting-tumor effects on transplanted S_(180) for mice and they could increase tumor- inhibitory rate. The secondary metabolites of Rhizotonia leguminicola have the immunopotentiation effects. It could increase the spleen index, stimulation index of T Lymphocyte and the phagocyte ability of Peritoneal Macrophages. The density of tumor cell was decreased, and degeneration and necrosis were also founded. |
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| Keywords: | Rhizoctonia leguminicola Swainsonine Adriamycin S_(180) Inhibiting-tumor effects |
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