Requirement for coronin 1 in T lymphocyte trafficking and cellular homeostasis |
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| Authors: | Föger Niko Rangell Linda Danilenko Dimitry M Chan Andrew C |
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| Institution: | Department of Immunology, Genentech, Incorporated, 1 DNA Way, South San Francisco, CA 94080, USA. |
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| Abstract: | The evolutionarily conserved actin-related protein (Arp2/3) complex is a key component of actin filament networks that is dynamically regulated by nucleation-promoting and inhibitory factors. Although much is known about actin assembly, the physiologic functions of inhibitory proteins are unclear. We generated coronin 1-/- mice and found that coronin 1 exerted an inhibitory effect on cellular steady-state F-actin formation via an Arp2/3-dependent mechanism. Whereas coronin 1 was required for chemokine-mediated migration, it was dispensable for T cell antigen receptor functions in T cells. Moreover, actin dynamics, through a mitochondrial pathway, was linked to lymphocyte homeostasis. |
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