| 亚硒酸钠在低硒籽鹅体内药物代谢动力学的研究 |
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| 引用本文： | 武瑞,贺显晶,杨颗粒,刘恩忠.亚硒酸钠在低硒籽鹅体内药物代谢动力学的研究[J].黑龙江八一农垦大学学报,2009,21(4):63-67. |
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| 作者姓名： | 武瑞 贺显晶 杨颗粒 刘恩忠 |
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| 作者单位： | 1. 黑龙江八一农垦大学动物科技学院,大庆,163319
2. 黑龙江省8511农场 |
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| 基金项目： | 黑龙江省科技厅攻关项目 |
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| 摘 要： | 研究亚硒酸钠在低硒籽鹅体内的药物代谢动力学,为临床合理地用药预防籽鹅缺硒病提供科学依据。选择1日龄健康籽鹅80只（公母各半）作试验动物,复制缺硒动物模型后,口服0.1%亚硒酸钠溶液,分别于投药后第0、1、2、4、8、12、24、48、72、96、144、192 h剖杀籽鹅,采取心脏、肝脏、肾脏、脾脏、胰脏、肌胃、肌肉组织样品,应用2,3—二氨基萘荧光法测定各组织中的硒含量,应用MCPKP软件计算药动学参数。肝脏、肾脏、脾脏、胰脏、肌胃均符合一级吸收二室开放模型,肌肉符合滞后一级吸收一室开放模型,心脏符合一级吸收一室开放模型。硒在肝脏中吸收最快,其次为心脏、肌胃、胰脏、肾脏、脾脏,肌肉吸收最慢;硒的消除都比较慢,最快的为肌肉,其次为心脏、肝脏、脾脏、肾脏、胰脏、肌胃。亚硒酸钠在低硒籽鹅不同组织中吸收、分布和消耗时间不同,这主要是由于硒缺乏损伤了动物机体的某些组织器官所致。
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| 关 键 词： | 亚硒酸钠 低硒籽鹅 药物代谢动力学 |
Study on the Tissue Pharmacokinetics of Sodium Selenite in Low-Selenium Zi Gooses |
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| Wu Rui,He Xianjing,Yang Keli,Liu Enzhong.Study on the Tissue Pharmacokinetics of Sodium Selenite in Low-Selenium Zi Gooses[J].Journal of Heilongjiang August First Land Reclamation University,2009,21(4):63-67. |
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| Authors: | Wu Rui He Xianjing Yang Keli Liu Enzhong |
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| Institution: | Wu Rui, He Xianjing, Yang Keli, Liu Enzhong ( 1 .College of Animal Science and Technology, Heilongjiang Bayi Agricultural University, Daqing 163319; 2. Heilongjiang Province 8511 farms ) |
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| Abstract: | To provide the scientific basis for the prevention of clinical selenium deficiency in Zi Gooses, this research has studied the tissue pharmacokinetics of sodium selenite in low-selenium Zi Gooses.80 Zi Gooses （1 day-old ）were subjected to establish selenium deficiency model, Zi Gooses were treated by oral administration of 0.1% sodium selenite after the selenium deficiency model was establishedsuccessfully.Theu,Zi Gooses were killed on 0,1,2,4,8,12,24,48,72,96,144,192 hours after oral administration ,and specimens, such as heart, liver, kidney, spleen, pancreas, muscular stomach and muscle ,were obtained. During the experiment, the selenium concentration in liver, kidney, spleen and muscular stomach were determined by 2,3-diamine naphthalene fluorescence method, then calculate the pharmacokiuetics parameters by MCPKPsoft were. The results show that the Pharmacokinetics of liver, kidney, spleen and muscular stomach was consistent with the two compartment open model with first order absorption; pancreas was consistent with the two compartment open model and first order absorption with a lagtimc; muscle was consistent with the one compartmeut open model and first order absorption with a lagtime; heart was consistent with the one compartment open model with first order absorption. The absorption of selenium in liver was the quickest, then heart, kidney, muscular stomach, pancreas and spleen,and muscle is the slowest. The elimination of selenium is slower than the deficiency selenium level and normal selenium level. Muscle was the quickest. Pancreas, then heart, kidney, muscular stomach, spleen and liver. The absorption, distribution and consumption of sodium selenite in different-organs of low-selenium Zi Gooses were various. the results indicate that there are some organs injury induced by selenium deficiency. |
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| Keywords: | sodium selenite low-selenium zi gooses pharmacokinetics |
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