Release of Trypanosoma congolense from the microcirculation of cattle by Berenil |
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| Authors: | MG Maxie GJ Losos |
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| Institution: | EAC/IDRC Project, East African Veterinary Research Organization, P.O. Box 32, Kikuyu Kenya |
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| Abstract: | Intravenous injection of Berenil (3.5 mg/kg) was followed in 5 min by an increase in the jugular blood parasite count of T. congolense-infected cattle. This increase was statistically significant between 5 and 10 min post Berenil injection. The peak parasitemia reached at 8 min post Berenil was 15 times greater than the pre-treatment parasitemia. It is suggested that the rise in jugular parasitemia results from release into the general circulation of T. congolense organisms which are localized in the microcirculation. Also, because a direct trypanocidal effect of Berenil was not observed in the blood held in vitro, it is suggested that Berenil acts by making trypanosomes available to host defenses, such as the macrophage system. |
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