Pharmacokinetics of Amoxicillin Trihydrate in Desert Sheep and Nubian Goats |
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| Authors: | Elsheikh HA Taha AA Khalafalla AE Osman IAM Wasfi IA |
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| Institution: | (1) Department of Veterinary Basic Sciences, Faculty of Veterinary Medicine, Jordan University of Science and Technology, PO Box 3030, Irbid, 22210, Jordan;(2) Department of Medicine, Pharmacology and Toxicology, Faculty of Veterinary Science, University of Khartoum, PO Box 32, Khartoum North, Sudan;(3) Camelracing Forensic Laboratory, PO Box 253, Abu Dhabi, United Arab Emirates |
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| Abstract: | The pharmacokinetics of amoxicillin were studied in five Desert sheep and five Nubian goats after intravenous (i.v.) or intramuscular (i.m.) administration of a single dose of 10 mg/kg body weight. Following i.v. injection, the plasma concentration-versus-time data were best described by a two-compartment open model. The kinetic variables were similar in both species except for the volume of the central compartment (Vc), which was larger in sheep (p<0.05). Following i.m. injection, except for the longer half-life time of absorption in goats (p<0.05), there were no significant differences in other pharmacokinetic parameters between sheep and goats. The route of amoxicillin administration had no significant effect on the terminal elimination half-life in either species. The bioavailability of the drug (F) after i.m. administration was high (>0.90) in both species. These results indicate that the pharmacokinetics of amoxicillin did not differ between sheep and goats; furthermore, because of the high availability and short half-life of absorption, the i.m. route gives similar results to the i.v. route. Therefore, identical intramuscular and intravenous dose regimens should be applicable to both species. |
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| Keywords: | amoxicillin bioavailability breed goats pharmacokinetics sheep |
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