| 狐胆汁对蟾蜍离体心脏功能的影响 |
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| 引用本文： | 薛艺,肖向红,张晶钰,刘志平,刘晶晶.狐胆汁对蟾蜍离体心脏功能的影响[J].野生动物,2011,32(4):217-220. |
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| 作者姓名： | 薛艺 肖向红 张晶钰 刘志平 刘晶晶 |
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| 作者单位： | 东北林业大学野生动物资源学院,哈尔滨,150040 |
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| 基金项目： | 国家"948"项目;项目 |
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| 摘 要： | 目的：研究狐胆汁对蟾蜍离体心脏的作用及对蟾蜍离体心脏细胞膜ATP酶活性的影响。方法：采用离体蛙心灌流法观察狐胆汁对离体蟾蜍心脏的收缩力、心率的影响,并通过定磷法检测狐胆汁对离体蟾蜍心肌细胞膜ATP酶活性的影响。结果：狐胆汁使蟾蜍离体心脏的收缩力加强,在0.3～4.0g/L浓度范围内,狐胆汁促进心肌收缩力的作用与剂量之间呈量效关系,最大效应可使心肌收缩力提高390%,心率减慢。随狐胆汁浓度提高,心肌细胞膜Ca^2＋-ATP酶活性提高,Na^＋K^＋-ATP酶、Mg^2＋-ATP酶、Ca^2＋Mg^2＋-ATP酶活性下降。结论：狐胆汁能提高蟾蜍离体心脏的功能,其作用机制有待进一步研究。
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| 关 键 词： | 狐胆汁 蛙心灌流 心肌收缩力 心率 心肌细胞膜ATP酶活性 |
Effects of Fox Lyophilized Bile Powder on the Cardiac Function of Isolated Toad Hearts |
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| Authors: | Xue Yi Xiao Xianghong Zhang Jingyu Liu Zhiping Liu Jingjing |
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| Institution: | Xue Yi Xiao Xianghong~* Zhang Jingyu Liu Zhiping Liu Jingjing (College of Wildlife Resources,Northeast Forestry University,Harbin,150040,China) |
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| Abstract: | Fox bile was a traditional Chinese medicine for treatment of sudden cardiac death.We investigated the effects of fox lyophilized bile powder on isolated toad hearts and studied the resulting ATPase activity of the myocardial membrane.We quantified the impact of fox lyophilized bile powder on cardiac contractility and heart rate of isolated toad hearts by perfusion,and also tested the impact of fox bile on the ATPase activity of myocardial membrane.Fox lyophilized bile powder stimulated isolated toad hearts,... |
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| Keywords: | Fox lyophilized bile powder Frog heart perfusion Cardiac contractility Heart rate ATPase activity of myocardial membrane |
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