| 马波沙星在罗非鱼体内的药物代谢动力学研究 |
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| 引用本文： | 单奇,白野,范晶晶,刘书贵,尹伊,李丽春,郑光明.马波沙星在罗非鱼体内的药物代谢动力学研究[J].华南农业大学学报,2017,38(1):5-8. |
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| 作者姓名： | 单奇 白野 范晶晶 刘书贵 尹伊 李丽春 郑光明 |
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| 作者单位： | 中国水产科学研究院 珠江水产研究所/农业部热带亚热带水产资源利用与养殖重点实验室/农业部水产品质量安全风险评估实验室,广东 广州,510380 |
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| 基金项目： | 国家自然科学基金（31502125）；广东省自然科学基金-博士启动基金（2015A030310086）；农业部水产品质量安全风险评估项目（GJFP201501001） |
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| 摘 要： | 【目的】研究马波沙星在罗非鱼Oreochromis niloticus体内的药物代谢动力学(简称药动学)特征,为临床合理用药提供参考。【方法】将罗非鱼随机分成2组,水温维持在30℃,以10 mg·kg-1分别单剂量肌内注射和口服给药,高效液相色谱(HPLC)-荧光检测法测定血浆中马波沙星的质量浓度,用Win Nonlin 6.1药动学软件的"非房室模型"分析药动学参数。【结果】肌内注射马波沙星后,药物吸收和消除均较口服快,体内分布广泛。达峰时间(tmax)为0.25 h,峰质量浓度(ρmax)为4.31μg·mL~(-1),消除半衰期(t1/2λz)为19.21 h,表观分布容积为3.94L·kg-1,药-时曲线下面积(AUC)为70.36μg·mL~(-1)·h-1。口服马波沙星后,药物吸收和消除均较慢,体内分布广泛。tmax为4.00 h,ρmax为2.45μg·mL~(-1),t1/2λz为22.67 h,表观分布容积为4.27 L·kg-1,AUC为76.66μg·mL~(-1)·h-1。【结论】10 mg·kg-1马波沙星能够有效治疗大多数敏感菌引起的罗非鱼感染。
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| 关 键 词： | 马波沙星 罗非鱼 药物代谢动力学 高效液相色谱 |
| 收稿时间： | 2016/4/1 0:00:00 |
Pharmacokinetics of marbofloxacin in tilapia (Oreochromis niloticus) |
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| SHAN Qi,BAI Ye,FAN Jingjing,LIU Shugui,YIN Yi,LI Lichun and ZHENG Guangming.Pharmacokinetics of marbofloxacin in tilapia (Oreochromis niloticus)[J].Journal of South China Agricultural University,2017,38(1):5-8. |
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| Authors: | SHAN Qi BAI Ye FAN Jingjing LIU Shugui YIN Yi LI Lichun and ZHENG Guangming |
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| Institution: | Pearl River Fisheries Research Institute, Chinese Academic of Fishery Science/Key Laboratory of Tropical and Subtropical Fishery Resource Application and Cultivation of Ministry of Agriculture/Ministry of Agriculture Laboratory of Quality & Safety Risky Assessment for Aquatic Product,,Pearl River Fisheries Research Institute, Chinese Academic of Fishery Science/Key Laboratory of Tropical and Subtropical Fishery Resource Application and Cultivation of Ministry of Agriculture/Ministry of Agriculture Laboratory of Quality & Safety Risky Assessment for Aquatic Product,,Pearl River Fisheries Research Institute, Chinese Academic of Fishery Science/Key Laboratory of Tropical and Subtropical Fishery Resource Application and Cultivation of Ministry of Agriculture/Ministry of Agriculture Laboratory of Quality & Safety Risky Assessment for Aquatic Product,,Pearl River Fisheries Research Institute, Chinese Academic of Fishery Science/Key Laboratory of Tropical and Subtropical Fishery Resource Application and Cultivation of Ministry of Agriculture/Ministry of Agriculture Laboratory of Quality & Safety Risky Assessment for Aquatic Product,,Pearl River Fisheries Research Institute, Chinese Academic of Fishery Science/Key Laboratory of Tropical and Subtropical Fishery Resource Application and Cultivation of Ministry of Agriculture/Ministry of Agriculture Laboratory of Quality & Safety Risky Assessment for Aquatic Product,,Pearl River Fisheries Research Institute, Chinese Academic of Fishery Science/Key Laboratory of Tropical and Subtropical Fishery Resource Application and Cultivation of Ministry of Agriculture/Ministry of Agriculture Laboratory of Quality & Safety Risky Assessment for Aquatic Product, and Pearl River Fisheries Research Institute, Chinese Academic of Fishery Science/Key Laboratory of Tropical and Subtropical Fishery Resource Application and Cultivation of Ministry of Agriculture/Ministry of Agriculture Laboratory of Quality & Safety Risky Assessment for Aquatic Product, |
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| Abstract: | Objective] To study the pharmacokinetics characteristics of marbofloxacin in tilapia ( Oreo-chromis niloticus) , and provide references for rational clinical drug usage.Method]The tilapia were di-vided into two groups for intramuscular ( i. m. ) and oral administrations, and each fish received marbo-floxacin at a dosage of 10 mg·kg-1 body mass. Water temperature was maintained at 30 ℃. The con-centration of marbofloxacin in plasma was measured using high performance liquid chromatography ( HPLC) combined with fluorescence detection. The plasma drug concentration-time data were analyzed by the non-compartment model of WinNonlin 6. 1 software.Result]After i. m. administration, marbo-floxacin absorption and elimination were relatively faster, and it was widely distributed throughout the body. Peak time of plasma concentration ( tmax ) was 0. 25 h, the maximum plasma concentration (ρmax ) was 4. 31 μg·mL-1 , the elimination half-life ( t1/2λz ) was 19. 21 h, the volume of distribution was 3. 94 L·kg-1 and the area under the plasma concentration-time curve ( AUC) was 70. 36 μg·mL-1·h-1 . Fol-lowing oral administration, marbofloxacin absorption and elimination were relatively slower, and it was widely distributed throughout the body. tmax was 4. 00 h, ρmax was 2. 45 μg·mL-1 , t1/2λz was 22. 67 h, the volume of distribution was 4. 27 L·kg-1 and AUC was 76. 66 μg·mL-1 ·h-1 .Conclusion]Using 10 mg·kg-1 marbofloxacin could effectively control susceptible micro-organisms involved in most com-mon infections in tilapia. |
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| Keywords: | marbofloxacin Oreochromis niloticus pharmacokinetics HPLC |
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