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pcdh19在小鼠毛囊形态发生过程中的时空表达
引用本文:孔德清,许晶莹,郁 枫,赵 磊,张若竹.pcdh19在小鼠毛囊形态发生过程中的时空表达[J].西北农业学报,2011,20(10):34-37.
作者姓名:孔德清  许晶莹  郁 枫  赵 磊  张若竹
作者单位:西北农林科技大学动物科技学院;西北农林科技大学林学院;
摘    要:以胚龄13.5 d到8日龄的昆白系小鼠为试验材料,应用免疫组化方法测定pcdh19在小鼠毛囊形态发生中表达的时空变化。结果显示,基板前期、基板期均未发现pcdh19的表达;毛芽期开始表皮和间充质胞质中出现弱表达,并且毛芽上的表达逐渐加强;在毛囊结缔组织鞘发生和成熟过程中,在该部位始终强表达,推测可将pcdh19作为结缔组织鞘的标志分子。

关 键 词:小鼠  毛囊形态发生  pcdh19  免疫组化

Temporal and Spatial Expressions of pcdh19 on Mouse Hair Follicle Morphogenesis
KONG Deqing,XU Jingying,YU Feng,ZHAO Lei and ZHANG Ruozhu.Temporal and Spatial Expressions of pcdh19 on Mouse Hair Follicle Morphogenesis[J].Acta Agriculturae Boreali-occidentalis Sinica,2011,20(10):34-37.
Authors:KONG Deqing  XU Jingying  YU Feng  ZHAO Lei and ZHANG Ruozhu
Institution:KONG Deqing1,XU Jingying2,YU Feng1,ZHAO Lei1 and ZHANG Ruozhu1(1.College of Animal Science and Technology,Northwest A&F University,Yangling Shaanxi 712100,China,2.College of Forestry,China)
Abstract:We have analyzed the expression pattern of protocadherin-19,a member of the δ-protocadherins,in the hair follicle and epidermis of developing mouse using immunohistochemical methods.Expression of pcdh19 was absent from the skin at pre-placode stage and hair placode stage.At hair germ stage it showed in epidermis and mesenchymal cells at a low expression level and increased in hair germ gradually.During the development and mature of hair follicle connective tissue sheath(CTS) pcdh19 expressed strongly at CTS.We speculate that pcdh19 could be regarded as a marker of hair follicle connective tissue sheath.
Keywords:Mouse  Hair follicle morphogenesis  pcdh19  Immunohistochemistry  
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