|
|||||
|
|
Implantation of exogenous enzymatic activity in isolated alveolar macrophages |
|
| Authors: | J Theodore J C Acevedo E D Robin |
| Abstract: | Alveolar macrophages acquired the capacity to oxidize uric acid after exposure to uricase. Presumably this resulted from intracellular incorporation of the enzyme by endocytosis. This approach may provide a general method for (i) testing regulatory biochemical mechanisms, (ii) therapeutic replacement of deficient regulatory macromolecules, and (iii) studying environmental factors that produce genetic alterations. |
| Keywords: | |