| 甲苯咪唑在鲫体内的药动学及残留消除研究 |
| |
| 引用本文： | 潘浩,王荻,卢彤岩.甲苯咪唑在鲫体内的药动学及残留消除研究[J].水产学杂志,2016(4):38-42. |
| |
| 作者姓名： | 潘浩 王荻 卢彤岩 |
| |
| 作者单位： | 1. 中国水产科学研究院黑龙江水产研究所，黑龙江 哈尔滨 150070; 上海海洋大学水产与生命学院，上海 201306;2. 中国水产科学研究院黑龙江水产研究所,黑龙江 哈尔滨,150070 |
| |
| 基金项目： | 公益性行业(农业)科研专项(201203085);渔药使用风险评估及其控制技术研究与示范;现代农业产业技术体系建设专项资金项目(CARS-46) |
| |
| 摘 要： | 在水温(20±0.5)℃下,给体质量(50±10)g的鲫Carassius auratus单剂量口灌20mg/kg(体质量)甲苯咪唑后0.25h、0.5h、0.75h、1h、1.5h、2h、4h、6h、8h、12h、24h、36h、48h,及72h,采集鲫血浆,利用高效液相色谱法测定血浆中药物的浓度,药动学DAS3.0软件进行数据分析和处理,研究甲苯咪唑在鱼体内的吸收和消除规律。结果表明:单次口灌给药后,甲苯咪唑在血浆中的药时关系符合一级吸收二室开放模型。每天给药一次,连续3d,氨基甲苯咪唑(MBZ-NH2)于25d后低于检测限(0.0465μg/m L)。在本试验条件下,建议休药期不低于25d。
|
| 关 键 词： | 甲苯咪唑 鲫 高效液相色谱法 药动学 残留 |
Pharmacokinetics and Residue Elimination of Mebendazole in Crucian Carp Carassius auratus |
| |
| PAN Hao;WANG Di;LU Tong-yan.Pharmacokinetics and Residue Elimination of Mebendazole in Crucian Carp Carassius auratus[J].Chinese Journal of Fisheries,2016(4):38-42. |
| |
| Authors: | PAN Hao;WANG Di;LU Tong-yan |
| |
| Institution: | PAN Hao;WANG Di;LU Tong-yan;Heilongjiang River Fisheries Research Institute, Chinese Academy of Fishery Sciences;College of Fisheries and Life Science, Shanghai Ocean University; |
| |
| Abstract: | The pharmacokinetics and residue elimination of mebendazole ( MBZ) were studied in crucian carp Carassius auratus with body weight of ( 50 ± 10) g exposed to oral administration of MBZ at dose of 20 mg/kg bodyweight by a means of high performance liquid chromatography( HPLC) at water temperature of( 20 ± 0.5) ℃. The drug concentrations in plasma were monitored in the cru-cian carp 0.25 h, 0.5 h, 0.75 h, 1 h, 1.5 h, 2 h, 4 h, 6 h, 8 h, 12 h, 24 h, 36 h, 48 h, and 72 h after drug administration, and analyzed by DAS 3.0 software. The results showed that the concentrations versus time of mebendazole in muscle were well described by two-de-partment open model with first-order absorption after a single oral administration. The residues in the crucian carp by oral administra-tion once a day for 3 d were found to be less than the maximum residue limit( MRL)( 0.0465 μg/mL) at the 25 d for MBZ. The find-ings indicate that the withdrawal time should be no less than 25 d after administration under these conditions. |
| |
| Keywords: | mebendazole Carassius auratus HPLC pharmacokinetics residue |
| 本文献已被 CNKI 万方数据 等数据库收录！ |
|
