Recovery of leptospires from miniature pigs experimentally infected with Leptospira interrogans serovar Manilae strain UP-MMC under immunosuppressive conditions by dexamethasone |
| |
| Authors: | Sakoda Yoshihiro Naito Michiko Ito Mutsumi Ito Yuki Isoda Norikazu Tanaka Tomohisa Umemura Takashi Kida Hiroshi |
| |
| Institution: | Laboratory of Microbiology, Department of Disease Control, Graduate School of Veterinary Medicine, Hokkaido University, Sapporo 060-0818, Japan. |
| |
| Abstract: | Leptospira interrogans serovar Manilae strain UP-MMC was inoculated into miniature pigs to assess its pathogenicity. Leptospires were recovered from the whole blood, kidneys, and livers in the acute phase without showing any clinical signs. Under immunosuppressive conditions by dexamethasone, leptospires were recovered from the kidneys and their genes were detected from the urine in the chronic phase. These results indicate that leptospires persisted in the kidneys until the chronic phase, and excretion of leptospires in the urine was enhanced under immunosuppressive conditions, resulting in horizontal transmission among pigs on farms. |
| |
| Keywords: | |
| 本文献已被 PubMed 等数据库收录！ |
|
