Some observations on the toxic effects of the seed extract ofSphenostylis stenocarpa (Hochst ex A. Rich) Harms. on intestinal muscle |
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| Authors: | I U Asuzu A Undie |
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| Institution: | (1) Department of Veterinary Physiology and Pharmacology, University of Nigeria, Nsukka;(2) Department of Pharmacology and Toxicology, University of Nigeria, Nsukka |
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| Abstract: | The effects of the water extract ofSphenostylis stenocarpa were observed on the guinea pig ileum and rabbit jejunum. The extract produced dose dependent — contractions of the guinea pig ileum with an ED50 of 3.664×10–5 g/ml and a calculated dose ratio of 1.25. The extract specifically stimulated muscarine receptors. Atropine (8×10–7 g/ml) caused a parallel shift to the right of the log dose — response curve in the guinea pig ileum suggesting a competitive antagonism. Boiling for about 12 h did not affect the contractile action of the extract on tissue preparations. However, boiling for 12–14 h completely abolished its contractile effect. Incubation of the extract with cholinestrerase at 37°C for 1 h did not abolish its contractile action on the intestine. |
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| Keywords: | Sphenostylis water extract antagonism muscarine receptor |
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