Long-term survival after combination chemotherapy for bilateral renal malignant lymphoma in a dog |
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| Authors: | Batchelor D J Bright S R Ibarrola P Tzannes S Blackwood L |
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| Institution: | Small Animal Hospital, Department of Clinical Veterinary Science, University of Liverpool, Crown St, Liverpool, L7 7EX, United Kingdom. danb@liv.ac.uk |
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| Abstract: | CASE HISTORY: A 6-year-old, entire male Flat-coated Retriever was presented with a history of lethargy, polydipsia and seizures. Clinical chemistry had shown marked azotaemia. CLINICAL FINDINGS AND DIAGNOSIS: Radiography and ultrasonography revealed bilateral renomegaly, and cytology of fine needle aspirates from the kidneys was diagnostic of malignant lymphoma. The dog was treated with a modified high-dose cyclophosphamide-, vincristine-, and prednisolone-based chemotherapy protocol, achieved remission, and returned to normal quality of life. Survival time was 346 days from the time of diagnosis. CLINICAL RELEVANCE: Malignant lymphoma in the kidneys of dogs has been considered to carry a uniformly poor prognosis. Long-term remission after medical treatment has not previously been reported. The favourable outcome in this case illustrates the limitations of clinical staging in determining the outcome for individual patients. |
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