| 利用植物生物反应器生产口服疫苗的进展 |
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| 引用本文： | 朱会英,吴存祥,胡宝忠,李文彬,韩天富.利用植物生物反应器生产口服疫苗的进展[J].分子植物育种,2004,2(3):443-448. |
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| 作者姓名： | 朱会英 吴存祥 胡宝忠 李文彬 韩天富 |
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| 作者单位： | 中国农业科学院作物科学研究所,北京,100081;东北农业大学生命科学学院,哈尔滨,150030;中国农业科学院作物科学研究所,北京,100081;东北农业大学生命科学学院,哈尔滨,150030 |
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| 基金项目： | 本研究得到国家重点基础研究发展计划(2002CB111301)、国家高技术研究发展计划和北京市自然科学基金(5042019)项目资助. |
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| 摘 要： | 利用植物生物反应器生产口服疫苗已成为目前研究的热点。与传统疫苗相比，植物源性疫苗具有安全、稳定、高效和廉价等优点。植物作为生产疫苗的载体可将抗原表达于植物的可食部位(例如种子和块茎)。当植物被食用或饲喂时，植物源性疫苗可激发保护性的黏膜免疫反应。随着生物技术的不断完善，植物生物反应器将会成为疫苗生产的有效途径，并部分替代传统疫苗的生产方式。本文综述了植物源性口服疫苗的研究进展，并对可能出现的问题及解决途径进行了探讨。
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| 关 键 词： | 植物 生物反应器 口服疫苗 免疫应答 |
Progress in Plant-derived Oral Vaccine Production |
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| Zhu Huiying Wu Cunxiang Hu Baozhong Li Wenbin Han Tianfu
Institute of Crop Science,The Chinese Academy of Agricultural Sciences,Beijing,
College of Life Science,Northeast Agricultural University,Harbin.Progress in Plant-derived Oral Vaccine Production[J].Molecular Plant Breeding,2004,2(3):443-448. |
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| Authors: | Zhu Huiying Wu Cunxiang Hu Baozhong Li Wenbin Han Tianfu
Institute of Crop Science The Chinese Academy of Agricultural Sciences Beijing College of Life Science Northeast Agricultural University Harbin |
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| Institution: | Zhu Huiying Wu Cunxiang Hu Baozhong Li Wenbin Han Tianfu
Institute of Crop Science,The Chinese Academy of Agricultural Sciences,Beijing,100081
College of Life Science,Northeast Agricultural University,Harbin,150030 |
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| Abstract: | Much attention has been focused on the plant-derived oral vaccine production. Compared with the traditional vaccines, the plant-derived oral vaccines are safe, stable, efficient and low-costed. Plant as the delivery vehicle for vaccine can express antigen in edible parts such as seeds and tubers. The plant-derived vaccine can induce protective mucosal immune responses when the transgenic plants are provided as food or feed. With the advances of plant biotechnology, plant bioreactor may become an available approach and will be an alternative means for vaccine production in the future. In this paper, the progresses in plant-derived oral vaccine were reviewed, and some problems that need to be resolved were also discussed. |
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| Keywords: | Plant Bioreactor Oral vaccine Immune response |
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